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An electrophysiological substrate of COVID-19
SARS-CoV-2 infection is associated with an increased risk of late cardiovascular (CV) outcomes. However, more data is needed to describe the electrophysiologic (EP) manifestation of post-acute CV sequelae of COVID-19. We compared two cohorts of adult patients with SARS-CoV-2 polymerase chain reactio...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Inc.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10027233/ https://www.ncbi.nlm.nih.gov/pubmed/36963283 http://dx.doi.org/10.1016/j.jelectrocard.2023.03.010 |
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author | Tereshchenko, Larisa G. Pourbemany, Jafar Haq, Kazi T. Patel, Hetal Hyde, Jessica Quadri, Suha Ibrahim, Habiba Tongpoon, Aaron Pourbemany, Reyhane Khan, Akram |
author_facet | Tereshchenko, Larisa G. Pourbemany, Jafar Haq, Kazi T. Patel, Hetal Hyde, Jessica Quadri, Suha Ibrahim, Habiba Tongpoon, Aaron Pourbemany, Reyhane Khan, Akram |
author_sort | Tereshchenko, Larisa G. |
collection | PubMed |
description | SARS-CoV-2 infection is associated with an increased risk of late cardiovascular (CV) outcomes. However, more data is needed to describe the electrophysiologic (EP) manifestation of post-acute CV sequelae of COVID-19. We compared two cohorts of adult patients with SARS-CoV-2 polymerase chain reaction (PCR) test and an electrocardiogram (ECG) performed between March 1, 2020, and September 13, 2020, in a retrospective double-cohort study, “Cardiovascular Risk Stratification in Covid-19” (CaVaR-Co19; NCT04555187). Patients with positive PCR comprised a COVID-19(+) cohort (n = 41; 61% women; 80% symptomatic), whereas patients with negative tests formed the COVID-19(−) cohort (n = 155; 56% women). In longitudinal analysis, comparing 3 ECGs recorded before, during, and on average 40 days after index COVID-19 episode, after adjustment for demographic and socioeconomic characteristics, baseline CV risk factors and comorbidities, use of prescription medications (including QT-prolonging drugs) before and during index COVID-19 episode, and the longitudinal changes in RR’ intervals, heart rhythm, and ventricular conduction type, only in the COVID-19(+) cohort QTc increased by +30.2(95% confidence interval [CI] 0.1–60.3) ms and the spatial ventricular gradient (SVG) elevation increased by +13.5(95%CI 1.2–25.9)°. In contrast, much smaller, statistically nonsignificant changes were observed in the COVID-19(−) cohort. In conclusion, post-acute CV sequelae of SARS-CoV-2 infection manifested on ECG by QTc prolongation and rotation of the SVG vector upward. |
format | Online Article Text |
id | pubmed-10027233 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-100272332023-03-21 An electrophysiological substrate of COVID-19 Tereshchenko, Larisa G. Pourbemany, Jafar Haq, Kazi T. Patel, Hetal Hyde, Jessica Quadri, Suha Ibrahim, Habiba Tongpoon, Aaron Pourbemany, Reyhane Khan, Akram J Electrocardiol Article SARS-CoV-2 infection is associated with an increased risk of late cardiovascular (CV) outcomes. However, more data is needed to describe the electrophysiologic (EP) manifestation of post-acute CV sequelae of COVID-19. We compared two cohorts of adult patients with SARS-CoV-2 polymerase chain reaction (PCR) test and an electrocardiogram (ECG) performed between March 1, 2020, and September 13, 2020, in a retrospective double-cohort study, “Cardiovascular Risk Stratification in Covid-19” (CaVaR-Co19; NCT04555187). Patients with positive PCR comprised a COVID-19(+) cohort (n = 41; 61% women; 80% symptomatic), whereas patients with negative tests formed the COVID-19(−) cohort (n = 155; 56% women). In longitudinal analysis, comparing 3 ECGs recorded before, during, and on average 40 days after index COVID-19 episode, after adjustment for demographic and socioeconomic characteristics, baseline CV risk factors and comorbidities, use of prescription medications (including QT-prolonging drugs) before and during index COVID-19 episode, and the longitudinal changes in RR’ intervals, heart rhythm, and ventricular conduction type, only in the COVID-19(+) cohort QTc increased by +30.2(95% confidence interval [CI] 0.1–60.3) ms and the spatial ventricular gradient (SVG) elevation increased by +13.5(95%CI 1.2–25.9)°. In contrast, much smaller, statistically nonsignificant changes were observed in the COVID-19(−) cohort. In conclusion, post-acute CV sequelae of SARS-CoV-2 infection manifested on ECG by QTc prolongation and rotation of the SVG vector upward. Elsevier Inc. 2023 2023-03-20 /pmc/articles/PMC10027233/ /pubmed/36963283 http://dx.doi.org/10.1016/j.jelectrocard.2023.03.010 Text en © 2023 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Tereshchenko, Larisa G. Pourbemany, Jafar Haq, Kazi T. Patel, Hetal Hyde, Jessica Quadri, Suha Ibrahim, Habiba Tongpoon, Aaron Pourbemany, Reyhane Khan, Akram An electrophysiological substrate of COVID-19 |
title | An electrophysiological substrate of COVID-19 |
title_full | An electrophysiological substrate of COVID-19 |
title_fullStr | An electrophysiological substrate of COVID-19 |
title_full_unstemmed | An electrophysiological substrate of COVID-19 |
title_short | An electrophysiological substrate of COVID-19 |
title_sort | electrophysiological substrate of covid-19 |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10027233/ https://www.ncbi.nlm.nih.gov/pubmed/36963283 http://dx.doi.org/10.1016/j.jelectrocard.2023.03.010 |
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