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An electrophysiological substrate of COVID-19

SARS-CoV-2 infection is associated with an increased risk of late cardiovascular (CV) outcomes. However, more data is needed to describe the electrophysiologic (EP) manifestation of post-acute CV sequelae of COVID-19. We compared two cohorts of adult patients with SARS-CoV-2 polymerase chain reactio...

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Autores principales: Tereshchenko, Larisa G., Pourbemany, Jafar, Haq, Kazi T., Patel, Hetal, Hyde, Jessica, Quadri, Suha, Ibrahim, Habiba, Tongpoon, Aaron, Pourbemany, Reyhane, Khan, Akram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10027233/
https://www.ncbi.nlm.nih.gov/pubmed/36963283
http://dx.doi.org/10.1016/j.jelectrocard.2023.03.010
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author Tereshchenko, Larisa G.
Pourbemany, Jafar
Haq, Kazi T.
Patel, Hetal
Hyde, Jessica
Quadri, Suha
Ibrahim, Habiba
Tongpoon, Aaron
Pourbemany, Reyhane
Khan, Akram
author_facet Tereshchenko, Larisa G.
Pourbemany, Jafar
Haq, Kazi T.
Patel, Hetal
Hyde, Jessica
Quadri, Suha
Ibrahim, Habiba
Tongpoon, Aaron
Pourbemany, Reyhane
Khan, Akram
author_sort Tereshchenko, Larisa G.
collection PubMed
description SARS-CoV-2 infection is associated with an increased risk of late cardiovascular (CV) outcomes. However, more data is needed to describe the electrophysiologic (EP) manifestation of post-acute CV sequelae of COVID-19. We compared two cohorts of adult patients with SARS-CoV-2 polymerase chain reaction (PCR) test and an electrocardiogram (ECG) performed between March 1, 2020, and September 13, 2020, in a retrospective double-cohort study, “Cardiovascular Risk Stratification in Covid-19” (CaVaR-Co19; NCT04555187). Patients with positive PCR comprised a COVID-19(+) cohort (n = 41; 61% women; 80% symptomatic), whereas patients with negative tests formed the COVID-19(−) cohort (n = 155; 56% women). In longitudinal analysis, comparing 3 ECGs recorded before, during, and on average 40 days after index COVID-19 episode, after adjustment for demographic and socioeconomic characteristics, baseline CV risk factors and comorbidities, use of prescription medications (including QT-prolonging drugs) before and during index COVID-19 episode, and the longitudinal changes in RR’ intervals, heart rhythm, and ventricular conduction type, only in the COVID-19(+) cohort QTc increased by +30.2(95% confidence interval [CI] 0.1–60.3) ms and the spatial ventricular gradient (SVG) elevation increased by +13.5(95%CI 1.2–25.9)°. In contrast, much smaller, statistically nonsignificant changes were observed in the COVID-19(−) cohort. In conclusion, post-acute CV sequelae of SARS-CoV-2 infection manifested on ECG by QTc prolongation and rotation of the SVG vector upward.
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spelling pubmed-100272332023-03-21 An electrophysiological substrate of COVID-19 Tereshchenko, Larisa G. Pourbemany, Jafar Haq, Kazi T. Patel, Hetal Hyde, Jessica Quadri, Suha Ibrahim, Habiba Tongpoon, Aaron Pourbemany, Reyhane Khan, Akram J Electrocardiol Article SARS-CoV-2 infection is associated with an increased risk of late cardiovascular (CV) outcomes. However, more data is needed to describe the electrophysiologic (EP) manifestation of post-acute CV sequelae of COVID-19. We compared two cohorts of adult patients with SARS-CoV-2 polymerase chain reaction (PCR) test and an electrocardiogram (ECG) performed between March 1, 2020, and September 13, 2020, in a retrospective double-cohort study, “Cardiovascular Risk Stratification in Covid-19” (CaVaR-Co19; NCT04555187). Patients with positive PCR comprised a COVID-19(+) cohort (n = 41; 61% women; 80% symptomatic), whereas patients with negative tests formed the COVID-19(−) cohort (n = 155; 56% women). In longitudinal analysis, comparing 3 ECGs recorded before, during, and on average 40 days after index COVID-19 episode, after adjustment for demographic and socioeconomic characteristics, baseline CV risk factors and comorbidities, use of prescription medications (including QT-prolonging drugs) before and during index COVID-19 episode, and the longitudinal changes in RR’ intervals, heart rhythm, and ventricular conduction type, only in the COVID-19(+) cohort QTc increased by +30.2(95% confidence interval [CI] 0.1–60.3) ms and the spatial ventricular gradient (SVG) elevation increased by +13.5(95%CI 1.2–25.9)°. In contrast, much smaller, statistically nonsignificant changes were observed in the COVID-19(−) cohort. In conclusion, post-acute CV sequelae of SARS-CoV-2 infection manifested on ECG by QTc prolongation and rotation of the SVG vector upward. Elsevier Inc. 2023 2023-03-20 /pmc/articles/PMC10027233/ /pubmed/36963283 http://dx.doi.org/10.1016/j.jelectrocard.2023.03.010 Text en © 2023 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Tereshchenko, Larisa G.
Pourbemany, Jafar
Haq, Kazi T.
Patel, Hetal
Hyde, Jessica
Quadri, Suha
Ibrahim, Habiba
Tongpoon, Aaron
Pourbemany, Reyhane
Khan, Akram
An electrophysiological substrate of COVID-19
title An electrophysiological substrate of COVID-19
title_full An electrophysiological substrate of COVID-19
title_fullStr An electrophysiological substrate of COVID-19
title_full_unstemmed An electrophysiological substrate of COVID-19
title_short An electrophysiological substrate of COVID-19
title_sort electrophysiological substrate of covid-19
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10027233/
https://www.ncbi.nlm.nih.gov/pubmed/36963283
http://dx.doi.org/10.1016/j.jelectrocard.2023.03.010
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