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Prefrontal tDCS modulates autonomic responses in COVID-19 inpatients
BACKGROUND: maladaptive changes in the autonomic nervous system (ANS) have been observed in short and long-term phases of COVID-19 infection. Identifying effective treatments to modulate autonomic imbalance could be a strategy for preventing and reducing disease severity and induced complications. O...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Authors. Published by Elsevier Inc.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10027235/ https://www.ncbi.nlm.nih.gov/pubmed/36940750 http://dx.doi.org/10.1016/j.brs.2023.03.001 |
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author | Pinto, Talita P. Inácio, Jacqueline C. de Aguiar, Erivelton Ferreira, Arthur S. Sudo, Felipe Kenji Tovar-Moll, Fernanda Rodrigues, Erika C. |
author_facet | Pinto, Talita P. Inácio, Jacqueline C. de Aguiar, Erivelton Ferreira, Arthur S. Sudo, Felipe Kenji Tovar-Moll, Fernanda Rodrigues, Erika C. |
author_sort | Pinto, Talita P. |
collection | PubMed |
description | BACKGROUND: maladaptive changes in the autonomic nervous system (ANS) have been observed in short and long-term phases of COVID-19 infection. Identifying effective treatments to modulate autonomic imbalance could be a strategy for preventing and reducing disease severity and induced complications. OBJECTIVE: to investigate the efficacy, safety, and feasibility of a single session of bihemispheric prefrontal tDCS on indicators of cardiac autonomic regulation and mood of COVID-19 inpatients. METHODS: patients were randomized to receive a single 30-min session of bihemispheric active tDCS over the dorsolateral prefrontal cortex (2 mA; n = 20) or sham (n = 20). Changes in time [post-pre intervention] in heart rate variability (HRV), mood, heart rate, respiratory rate, and oxygen saturation were compared between groups. Additionally, clinical worsening indicators and the occurrence of falls and skin injuries were evaluated. The Brunoni Adverse Effects Questionary was employed after the intervention. RESULTS: there was a large effect size (Hedges’ g = 0.7) of intervention on HRV frequency parameters, suggesting alterations in cardiac autonomic regulation. An increment in oxygen saturation was observed in the active group but not in the sham after the intervention (P = 0.045). There were no group differences regarding mood, incidence and intensity of adverse effects, no occurrence of skin lesions, falls, or clinical worsening. CONCLUSIONS: a single prefrontal tDCS session is safe and feasible to modulate indicators of cardiac autonomic regulation in acute COVID-19 inpatients. Further research comprising a thorough assessment of autonomic function and inflammatory biomarkers is required to verify its potential to manage autonomic dysfunctions, mitigate inflammatory responses and enhance clinical outcomes. |
format | Online Article Text |
id | pubmed-10027235 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | The Authors. Published by Elsevier Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-100272352023-03-21 Prefrontal tDCS modulates autonomic responses in COVID-19 inpatients Pinto, Talita P. Inácio, Jacqueline C. de Aguiar, Erivelton Ferreira, Arthur S. Sudo, Felipe Kenji Tovar-Moll, Fernanda Rodrigues, Erika C. Brain Stimul Article BACKGROUND: maladaptive changes in the autonomic nervous system (ANS) have been observed in short and long-term phases of COVID-19 infection. Identifying effective treatments to modulate autonomic imbalance could be a strategy for preventing and reducing disease severity and induced complications. OBJECTIVE: to investigate the efficacy, safety, and feasibility of a single session of bihemispheric prefrontal tDCS on indicators of cardiac autonomic regulation and mood of COVID-19 inpatients. METHODS: patients were randomized to receive a single 30-min session of bihemispheric active tDCS over the dorsolateral prefrontal cortex (2 mA; n = 20) or sham (n = 20). Changes in time [post-pre intervention] in heart rate variability (HRV), mood, heart rate, respiratory rate, and oxygen saturation were compared between groups. Additionally, clinical worsening indicators and the occurrence of falls and skin injuries were evaluated. The Brunoni Adverse Effects Questionary was employed after the intervention. RESULTS: there was a large effect size (Hedges’ g = 0.7) of intervention on HRV frequency parameters, suggesting alterations in cardiac autonomic regulation. An increment in oxygen saturation was observed in the active group but not in the sham after the intervention (P = 0.045). There were no group differences regarding mood, incidence and intensity of adverse effects, no occurrence of skin lesions, falls, or clinical worsening. CONCLUSIONS: a single prefrontal tDCS session is safe and feasible to modulate indicators of cardiac autonomic regulation in acute COVID-19 inpatients. Further research comprising a thorough assessment of autonomic function and inflammatory biomarkers is required to verify its potential to manage autonomic dysfunctions, mitigate inflammatory responses and enhance clinical outcomes. The Authors. Published by Elsevier Inc. 2023 2023-03-20 /pmc/articles/PMC10027235/ /pubmed/36940750 http://dx.doi.org/10.1016/j.brs.2023.03.001 Text en © 2023 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Pinto, Talita P. Inácio, Jacqueline C. de Aguiar, Erivelton Ferreira, Arthur S. Sudo, Felipe Kenji Tovar-Moll, Fernanda Rodrigues, Erika C. Prefrontal tDCS modulates autonomic responses in COVID-19 inpatients |
title | Prefrontal tDCS modulates autonomic responses in COVID-19 inpatients |
title_full | Prefrontal tDCS modulates autonomic responses in COVID-19 inpatients |
title_fullStr | Prefrontal tDCS modulates autonomic responses in COVID-19 inpatients |
title_full_unstemmed | Prefrontal tDCS modulates autonomic responses in COVID-19 inpatients |
title_short | Prefrontal tDCS modulates autonomic responses in COVID-19 inpatients |
title_sort | prefrontal tdcs modulates autonomic responses in covid-19 inpatients |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10027235/ https://www.ncbi.nlm.nih.gov/pubmed/36940750 http://dx.doi.org/10.1016/j.brs.2023.03.001 |
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