Cellular and molecular features of COVID-19 associated ARDS: therapeutic relevance

The severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection can be asymptomatic or cause a disease (COVID-19) characterized by different levels of severity. The main cause of severe COVID-19 and death is represented by acute (or acute on chronic) respiratory failure and acute respirat...

Descripción completa

Detalles Bibliográficos
Autores principales: Scaramuzzo, Gaetano, Nucera, Francesco, Asmundo, Alessio, Messina, Roberto, Mari, Matilde, Montanaro, Federica, Johansen, Matt D., Monaco, Francesco, Fadda, Guido, Tuccari, Giovanni, Hansbro, Nicole G., Hansbro, Philip M., Hansel, Trevor T., Adcock, Ian M., David, Antonio, Kirkham, Paul, Caramori, Gaetano, Volta, Carlo Alberto, Spadaro, Savino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10027286/
https://www.ncbi.nlm.nih.gov/pubmed/36941580
http://dx.doi.org/10.1186/s12950-023-00333-2
Descripción
Sumario:The severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection can be asymptomatic or cause a disease (COVID-19) characterized by different levels of severity. The main cause of severe COVID-19 and death is represented by acute (or acute on chronic) respiratory failure and acute respiratory distress syndrome (ARDS), often requiring hospital admission and ventilator support. The molecular pathogenesis of COVID-19-related ARDS (by now termed c-ARDS) is still poorly understood. In this review we will discuss the genetic susceptibility to COVID-19, the pathogenesis and the local and systemic biomarkers correlated with c-ARDS and the therapeutic options that target the cell signalling pathways of c-ARDS.

Ejemplares similares