Cellular and molecular features of COVID-19 associated ARDS: therapeutic relevance

The severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection can be asymptomatic or cause a disease (COVID-19) characterized by different levels of severity. The main cause of severe COVID-19 and death is represented by acute (or acute on chronic) respiratory failure and acute respirat...

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Autores principales: Scaramuzzo, Gaetano, Nucera, Francesco, Asmundo, Alessio, Messina, Roberto, Mari, Matilde, Montanaro, Federica, Johansen, Matt D., Monaco, Francesco, Fadda, Guido, Tuccari, Giovanni, Hansbro, Nicole G., Hansbro, Philip M., Hansel, Trevor T., Adcock, Ian M., David, Antonio, Kirkham, Paul, Caramori, Gaetano, Volta, Carlo Alberto, Spadaro, Savino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10027286/
https://www.ncbi.nlm.nih.gov/pubmed/36941580
http://dx.doi.org/10.1186/s12950-023-00333-2
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author Scaramuzzo, Gaetano
Nucera, Francesco
Asmundo, Alessio
Messina, Roberto
Mari, Matilde
Montanaro, Federica
Johansen, Matt D.
Monaco, Francesco
Fadda, Guido
Tuccari, Giovanni
Hansbro, Nicole G.
Hansbro, Philip M.
Hansel, Trevor T.
Adcock, Ian M.
David, Antonio
Kirkham, Paul
Caramori, Gaetano
Volta, Carlo Alberto
Spadaro, Savino
author_facet Scaramuzzo, Gaetano
Nucera, Francesco
Asmundo, Alessio
Messina, Roberto
Mari, Matilde
Montanaro, Federica
Johansen, Matt D.
Monaco, Francesco
Fadda, Guido
Tuccari, Giovanni
Hansbro, Nicole G.
Hansbro, Philip M.
Hansel, Trevor T.
Adcock, Ian M.
David, Antonio
Kirkham, Paul
Caramori, Gaetano
Volta, Carlo Alberto
Spadaro, Savino
author_sort Scaramuzzo, Gaetano
collection PubMed
description The severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection can be asymptomatic or cause a disease (COVID-19) characterized by different levels of severity. The main cause of severe COVID-19 and death is represented by acute (or acute on chronic) respiratory failure and acute respiratory distress syndrome (ARDS), often requiring hospital admission and ventilator support. The molecular pathogenesis of COVID-19-related ARDS (by now termed c-ARDS) is still poorly understood. In this review we will discuss the genetic susceptibility to COVID-19, the pathogenesis and the local and systemic biomarkers correlated with c-ARDS and the therapeutic options that target the cell signalling pathways of c-ARDS.
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spelling pubmed-100272862023-03-21 Cellular and molecular features of COVID-19 associated ARDS: therapeutic relevance Scaramuzzo, Gaetano Nucera, Francesco Asmundo, Alessio Messina, Roberto Mari, Matilde Montanaro, Federica Johansen, Matt D. Monaco, Francesco Fadda, Guido Tuccari, Giovanni Hansbro, Nicole G. Hansbro, Philip M. Hansel, Trevor T. Adcock, Ian M. David, Antonio Kirkham, Paul Caramori, Gaetano Volta, Carlo Alberto Spadaro, Savino J Inflamm (Lond) Review The severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection can be asymptomatic or cause a disease (COVID-19) characterized by different levels of severity. The main cause of severe COVID-19 and death is represented by acute (or acute on chronic) respiratory failure and acute respiratory distress syndrome (ARDS), often requiring hospital admission and ventilator support. The molecular pathogenesis of COVID-19-related ARDS (by now termed c-ARDS) is still poorly understood. In this review we will discuss the genetic susceptibility to COVID-19, the pathogenesis and the local and systemic biomarkers correlated with c-ARDS and the therapeutic options that target the cell signalling pathways of c-ARDS. BioMed Central 2023-03-20 /pmc/articles/PMC10027286/ /pubmed/36941580 http://dx.doi.org/10.1186/s12950-023-00333-2 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Scaramuzzo, Gaetano
Nucera, Francesco
Asmundo, Alessio
Messina, Roberto
Mari, Matilde
Montanaro, Federica
Johansen, Matt D.
Monaco, Francesco
Fadda, Guido
Tuccari, Giovanni
Hansbro, Nicole G.
Hansbro, Philip M.
Hansel, Trevor T.
Adcock, Ian M.
David, Antonio
Kirkham, Paul
Caramori, Gaetano
Volta, Carlo Alberto
Spadaro, Savino
Cellular and molecular features of COVID-19 associated ARDS: therapeutic relevance
title Cellular and molecular features of COVID-19 associated ARDS: therapeutic relevance
title_full Cellular and molecular features of COVID-19 associated ARDS: therapeutic relevance
title_fullStr Cellular and molecular features of COVID-19 associated ARDS: therapeutic relevance
title_full_unstemmed Cellular and molecular features of COVID-19 associated ARDS: therapeutic relevance
title_short Cellular and molecular features of COVID-19 associated ARDS: therapeutic relevance
title_sort cellular and molecular features of covid-19 associated ards: therapeutic relevance
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10027286/
https://www.ncbi.nlm.nih.gov/pubmed/36941580
http://dx.doi.org/10.1186/s12950-023-00333-2
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