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Inherited mutations affecting the SRCAP complex are central in moderate-penetrance predisposition to uterine leiomyomas

Uterine leiomyomas (ULs) are benign smooth muscle tumors that are common in premenopausal women. Somatic alterations in MED12, HMGA2, FH, genes encoding subunits of the SRCAP complex, and genes involved in Cullin 3-RING E3 ligase neddylation are mutually exclusive UL drivers. Established predisposit...

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Detalles Bibliográficos
Autores principales:	Välimäki, Niko, Jokinen, Vilja, Cajuso, Tatiana, Kuisma, Heli, Taira, Aurora, Dagnaud, Olivia, Ilves, Sini, Kaukomaa, Jaana, Pasanen, Annukka, Palin, Kimmo, Heikinheimo, Oskari, Bützow, Ralf, Aaltonen, Lauri A., Karhu, Auli
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10027472/ https://www.ncbi.nlm.nih.gov/pubmed/36773604 http://dx.doi.org/10.1016/j.ajhg.2023.01.009

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