Hepatocyte estrogen sulfotransferase inhibition protects female mice from concanavalin A–induced T cell–mediated hepatitis independent of estrogens

Autoimmune hepatitis (AIH) is a typical T cell–mediated chronic liver disease with a higher incidence in females. However, the molecular mechanism for the female predisposition is poorly understood. Estrogen sulfotransferase (Est) is a conjugating enzyme best known for its function in sulfonating an...

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Detalles Bibliográficos
Autores principales: Wang, Jingyuan, Zhang, Ziteng, Guan, Jibin, Tung, Hung-Chun, Xie, Jiaxuan, Huang, Haozhe, Chen, Yuang, Xu, Meishu, Ren, Songrong, Li, Song, Zhang, Min, Yang, Da, Xie, Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10027562/
https://www.ncbi.nlm.nih.gov/pubmed/36796516
http://dx.doi.org/10.1016/j.jbc.2023.103026

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