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Effect of geographical factors on reference values of creatine kinase isoenzyme
The aim of this study was to investigate the geographical spatial distribution of creatine kinase isoenzyme (CK-MB) in order to provide a scientific basis for clinical examination. The reference values of CK-MB of 8697 healthy adults in 137 cities in China were collected by reading a large number of...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10027583/ https://www.ncbi.nlm.nih.gov/pubmed/36941512 http://dx.doi.org/10.1007/s00484-023-02429-z |
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author | Pang, Xinrui Ge, Miao |
author_facet | Pang, Xinrui Ge, Miao |
author_sort | Pang, Xinrui |
collection | PubMed |
description | The aim of this study was to investigate the geographical spatial distribution of creatine kinase isoenzyme (CK-MB) in order to provide a scientific basis for clinical examination. The reference values of CK-MB of 8697 healthy adults in 137 cities in China were collected by reading a large number of literates. Moran index was used to determine the spatial relationship, and 24 factors were selected, which belonged to terrain, climate, and soil indexes. Correlation analysis was conducted between CK-MB and geographical factors to determine significance, and 9 significance factors were extracted. Based on R language to evaluate the degree of multicollinearity of the model, CK-MB Ridge model, Lasso model, and PCA model were established, through calculating the relative error to choose the best model PCA, testing the normality of the predicted values, and choosing the disjunctive kriging interpolation to make the geographical distribution. The results show that CK-MB reference values of healthy adults were generally correlated with latitude, annual sunshine duration, annual mean relative humidity, annual precipitation amount, and annual range of air temperature and significantly correlated with annual mean air temperature, topsoil gravel content, topsoil cation exchange capacity in clay, and topsoil cation exchange capacity in silt. The geospatial distribution map shows that on the whole, it is higher in the north and lower in the south, and gradually increases from the southeast coastal area to the northwest inland area. If the geographical factors are obtained in a location, the CK-MB model can be used to predict the CK-MB of healthy adults in the region, which provides a reference for us to consider regional differences in clinical diagnosis. |
format | Online Article Text |
id | pubmed-10027583 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-100275832023-03-21 Effect of geographical factors on reference values of creatine kinase isoenzyme Pang, Xinrui Ge, Miao Int J Biometeorol Original Paper The aim of this study was to investigate the geographical spatial distribution of creatine kinase isoenzyme (CK-MB) in order to provide a scientific basis for clinical examination. The reference values of CK-MB of 8697 healthy adults in 137 cities in China were collected by reading a large number of literates. Moran index was used to determine the spatial relationship, and 24 factors were selected, which belonged to terrain, climate, and soil indexes. Correlation analysis was conducted between CK-MB and geographical factors to determine significance, and 9 significance factors were extracted. Based on R language to evaluate the degree of multicollinearity of the model, CK-MB Ridge model, Lasso model, and PCA model were established, through calculating the relative error to choose the best model PCA, testing the normality of the predicted values, and choosing the disjunctive kriging interpolation to make the geographical distribution. The results show that CK-MB reference values of healthy adults were generally correlated with latitude, annual sunshine duration, annual mean relative humidity, annual precipitation amount, and annual range of air temperature and significantly correlated with annual mean air temperature, topsoil gravel content, topsoil cation exchange capacity in clay, and topsoil cation exchange capacity in silt. The geospatial distribution map shows that on the whole, it is higher in the north and lower in the south, and gradually increases from the southeast coastal area to the northwest inland area. If the geographical factors are obtained in a location, the CK-MB model can be used to predict the CK-MB of healthy adults in the region, which provides a reference for us to consider regional differences in clinical diagnosis. Springer Berlin Heidelberg 2023-03-21 2023 /pmc/articles/PMC10027583/ /pubmed/36941512 http://dx.doi.org/10.1007/s00484-023-02429-z Text en © The Author(s) under exclusive licence to International Society of Biometeorology 2023, Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Original Paper Pang, Xinrui Ge, Miao Effect of geographical factors on reference values of creatine kinase isoenzyme |
title | Effect of geographical factors on reference values of creatine kinase isoenzyme |
title_full | Effect of geographical factors on reference values of creatine kinase isoenzyme |
title_fullStr | Effect of geographical factors on reference values of creatine kinase isoenzyme |
title_full_unstemmed | Effect of geographical factors on reference values of creatine kinase isoenzyme |
title_short | Effect of geographical factors on reference values of creatine kinase isoenzyme |
title_sort | effect of geographical factors on reference values of creatine kinase isoenzyme |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10027583/ https://www.ncbi.nlm.nih.gov/pubmed/36941512 http://dx.doi.org/10.1007/s00484-023-02429-z |
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