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Global Dynamics of Porcine Enteric Coronavirus PEDV Epidemiology, Evolution, and Transmission

With a possible origin from bats, the alphacoronavirus Porcine epidemic diarrhea virus (PEDV) causes significant hazards and widespread epidemics in the swine population. However, the ecology, evolution, and spread of PEDV are still unclear. Here, from 149,869 fecal and intestinal tissue samples of...

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Autores principales: Zhang, Hao, Zou, Chuangchao, Peng, Ouyang, Ashraf, Usama, Xu, Qiuping, Gong, Lang, Fan, Baochao, Zhang, Yun, Xu, Zhichao, Xue, Chunyi, Wei, Xiaona, Zhou, Qingfeng, Tian, Xiaoyan, Shen, Hanqin, Li, Bin, Zhang, Xiangbin, Cao, Yongchang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10027654/
https://www.ncbi.nlm.nih.gov/pubmed/36869744
http://dx.doi.org/10.1093/molbev/msad052
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author Zhang, Hao
Zou, Chuangchao
Peng, Ouyang
Ashraf, Usama
Xu, Qiuping
Gong, Lang
Fan, Baochao
Zhang, Yun
Xu, Zhichao
Xue, Chunyi
Wei, Xiaona
Zhou, Qingfeng
Tian, Xiaoyan
Shen, Hanqin
Li, Bin
Zhang, Xiangbin
Cao, Yongchang
author_facet Zhang, Hao
Zou, Chuangchao
Peng, Ouyang
Ashraf, Usama
Xu, Qiuping
Gong, Lang
Fan, Baochao
Zhang, Yun
Xu, Zhichao
Xue, Chunyi
Wei, Xiaona
Zhou, Qingfeng
Tian, Xiaoyan
Shen, Hanqin
Li, Bin
Zhang, Xiangbin
Cao, Yongchang
author_sort Zhang, Hao
collection PubMed
description With a possible origin from bats, the alphacoronavirus Porcine epidemic diarrhea virus (PEDV) causes significant hazards and widespread epidemics in the swine population. However, the ecology, evolution, and spread of PEDV are still unclear. Here, from 149,869 fecal and intestinal tissue samples of pigs collected in an 11-year survey, we identified PEDV as the most dominant virus in diarrheal animals. Global whole genomic and evolutionary analyses of 672 PEDV strains revealed the fast-evolving PEDV genotype 2 (G2) strains as the main epidemic viruses worldwide, which seems to correlate with the use of G2-targeting vaccines. The evolving pattern of the G2 viruses presents geographic bias as they evolve tachytely in South Korea but undergo the highest recombination in China. Therefore, we clustered six PEDV haplotypes in China, whereas South Korea held five haplotypes, including a unique haplotype G. In addition, an assessment of the spatiotemporal spread route of PEDV indicates Germany and Japan as the primary hubs for PEDV dissemination in Europe and Asia, respectively. Overall, our findings provide novel insights into the epidemiology, evolution, and transmission of PEDV, and thus may lay a foundation for the prevention and control of PEDV and other coronaviruses.
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spelling pubmed-100276542023-03-22 Global Dynamics of Porcine Enteric Coronavirus PEDV Epidemiology, Evolution, and Transmission Zhang, Hao Zou, Chuangchao Peng, Ouyang Ashraf, Usama Xu, Qiuping Gong, Lang Fan, Baochao Zhang, Yun Xu, Zhichao Xue, Chunyi Wei, Xiaona Zhou, Qingfeng Tian, Xiaoyan Shen, Hanqin Li, Bin Zhang, Xiangbin Cao, Yongchang Mol Biol Evol Discoveries With a possible origin from bats, the alphacoronavirus Porcine epidemic diarrhea virus (PEDV) causes significant hazards and widespread epidemics in the swine population. However, the ecology, evolution, and spread of PEDV are still unclear. Here, from 149,869 fecal and intestinal tissue samples of pigs collected in an 11-year survey, we identified PEDV as the most dominant virus in diarrheal animals. Global whole genomic and evolutionary analyses of 672 PEDV strains revealed the fast-evolving PEDV genotype 2 (G2) strains as the main epidemic viruses worldwide, which seems to correlate with the use of G2-targeting vaccines. The evolving pattern of the G2 viruses presents geographic bias as they evolve tachytely in South Korea but undergo the highest recombination in China. Therefore, we clustered six PEDV haplotypes in China, whereas South Korea held five haplotypes, including a unique haplotype G. In addition, an assessment of the spatiotemporal spread route of PEDV indicates Germany and Japan as the primary hubs for PEDV dissemination in Europe and Asia, respectively. Overall, our findings provide novel insights into the epidemiology, evolution, and transmission of PEDV, and thus may lay a foundation for the prevention and control of PEDV and other coronaviruses. Oxford University Press 2023-03-03 /pmc/articles/PMC10027654/ /pubmed/36869744 http://dx.doi.org/10.1093/molbev/msad052 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of Society for Molecular Biology and Evolution. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Discoveries
Zhang, Hao
Zou, Chuangchao
Peng, Ouyang
Ashraf, Usama
Xu, Qiuping
Gong, Lang
Fan, Baochao
Zhang, Yun
Xu, Zhichao
Xue, Chunyi
Wei, Xiaona
Zhou, Qingfeng
Tian, Xiaoyan
Shen, Hanqin
Li, Bin
Zhang, Xiangbin
Cao, Yongchang
Global Dynamics of Porcine Enteric Coronavirus PEDV Epidemiology, Evolution, and Transmission
title Global Dynamics of Porcine Enteric Coronavirus PEDV Epidemiology, Evolution, and Transmission
title_full Global Dynamics of Porcine Enteric Coronavirus PEDV Epidemiology, Evolution, and Transmission
title_fullStr Global Dynamics of Porcine Enteric Coronavirus PEDV Epidemiology, Evolution, and Transmission
title_full_unstemmed Global Dynamics of Porcine Enteric Coronavirus PEDV Epidemiology, Evolution, and Transmission
title_short Global Dynamics of Porcine Enteric Coronavirus PEDV Epidemiology, Evolution, and Transmission
title_sort global dynamics of porcine enteric coronavirus pedv epidemiology, evolution, and transmission
topic Discoveries
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10027654/
https://www.ncbi.nlm.nih.gov/pubmed/36869744
http://dx.doi.org/10.1093/molbev/msad052
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