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Global Dynamics of Porcine Enteric Coronavirus PEDV Epidemiology, Evolution, and Transmission
With a possible origin from bats, the alphacoronavirus Porcine epidemic diarrhea virus (PEDV) causes significant hazards and widespread epidemics in the swine population. However, the ecology, evolution, and spread of PEDV are still unclear. Here, from 149,869 fecal and intestinal tissue samples of...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10027654/ https://www.ncbi.nlm.nih.gov/pubmed/36869744 http://dx.doi.org/10.1093/molbev/msad052 |
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author | Zhang, Hao Zou, Chuangchao Peng, Ouyang Ashraf, Usama Xu, Qiuping Gong, Lang Fan, Baochao Zhang, Yun Xu, Zhichao Xue, Chunyi Wei, Xiaona Zhou, Qingfeng Tian, Xiaoyan Shen, Hanqin Li, Bin Zhang, Xiangbin Cao, Yongchang |
author_facet | Zhang, Hao Zou, Chuangchao Peng, Ouyang Ashraf, Usama Xu, Qiuping Gong, Lang Fan, Baochao Zhang, Yun Xu, Zhichao Xue, Chunyi Wei, Xiaona Zhou, Qingfeng Tian, Xiaoyan Shen, Hanqin Li, Bin Zhang, Xiangbin Cao, Yongchang |
author_sort | Zhang, Hao |
collection | PubMed |
description | With a possible origin from bats, the alphacoronavirus Porcine epidemic diarrhea virus (PEDV) causes significant hazards and widespread epidemics in the swine population. However, the ecology, evolution, and spread of PEDV are still unclear. Here, from 149,869 fecal and intestinal tissue samples of pigs collected in an 11-year survey, we identified PEDV as the most dominant virus in diarrheal animals. Global whole genomic and evolutionary analyses of 672 PEDV strains revealed the fast-evolving PEDV genotype 2 (G2) strains as the main epidemic viruses worldwide, which seems to correlate with the use of G2-targeting vaccines. The evolving pattern of the G2 viruses presents geographic bias as they evolve tachytely in South Korea but undergo the highest recombination in China. Therefore, we clustered six PEDV haplotypes in China, whereas South Korea held five haplotypes, including a unique haplotype G. In addition, an assessment of the spatiotemporal spread route of PEDV indicates Germany and Japan as the primary hubs for PEDV dissemination in Europe and Asia, respectively. Overall, our findings provide novel insights into the epidemiology, evolution, and transmission of PEDV, and thus may lay a foundation for the prevention and control of PEDV and other coronaviruses. |
format | Online Article Text |
id | pubmed-10027654 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-100276542023-03-22 Global Dynamics of Porcine Enteric Coronavirus PEDV Epidemiology, Evolution, and Transmission Zhang, Hao Zou, Chuangchao Peng, Ouyang Ashraf, Usama Xu, Qiuping Gong, Lang Fan, Baochao Zhang, Yun Xu, Zhichao Xue, Chunyi Wei, Xiaona Zhou, Qingfeng Tian, Xiaoyan Shen, Hanqin Li, Bin Zhang, Xiangbin Cao, Yongchang Mol Biol Evol Discoveries With a possible origin from bats, the alphacoronavirus Porcine epidemic diarrhea virus (PEDV) causes significant hazards and widespread epidemics in the swine population. However, the ecology, evolution, and spread of PEDV are still unclear. Here, from 149,869 fecal and intestinal tissue samples of pigs collected in an 11-year survey, we identified PEDV as the most dominant virus in diarrheal animals. Global whole genomic and evolutionary analyses of 672 PEDV strains revealed the fast-evolving PEDV genotype 2 (G2) strains as the main epidemic viruses worldwide, which seems to correlate with the use of G2-targeting vaccines. The evolving pattern of the G2 viruses presents geographic bias as they evolve tachytely in South Korea but undergo the highest recombination in China. Therefore, we clustered six PEDV haplotypes in China, whereas South Korea held five haplotypes, including a unique haplotype G. In addition, an assessment of the spatiotemporal spread route of PEDV indicates Germany and Japan as the primary hubs for PEDV dissemination in Europe and Asia, respectively. Overall, our findings provide novel insights into the epidemiology, evolution, and transmission of PEDV, and thus may lay a foundation for the prevention and control of PEDV and other coronaviruses. Oxford University Press 2023-03-03 /pmc/articles/PMC10027654/ /pubmed/36869744 http://dx.doi.org/10.1093/molbev/msad052 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of Society for Molecular Biology and Evolution. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Discoveries Zhang, Hao Zou, Chuangchao Peng, Ouyang Ashraf, Usama Xu, Qiuping Gong, Lang Fan, Baochao Zhang, Yun Xu, Zhichao Xue, Chunyi Wei, Xiaona Zhou, Qingfeng Tian, Xiaoyan Shen, Hanqin Li, Bin Zhang, Xiangbin Cao, Yongchang Global Dynamics of Porcine Enteric Coronavirus PEDV Epidemiology, Evolution, and Transmission |
title | Global Dynamics of Porcine Enteric Coronavirus PEDV Epidemiology, Evolution, and Transmission |
title_full | Global Dynamics of Porcine Enteric Coronavirus PEDV Epidemiology, Evolution, and Transmission |
title_fullStr | Global Dynamics of Porcine Enteric Coronavirus PEDV Epidemiology, Evolution, and Transmission |
title_full_unstemmed | Global Dynamics of Porcine Enteric Coronavirus PEDV Epidemiology, Evolution, and Transmission |
title_short | Global Dynamics of Porcine Enteric Coronavirus PEDV Epidemiology, Evolution, and Transmission |
title_sort | global dynamics of porcine enteric coronavirus pedv epidemiology, evolution, and transmission |
topic | Discoveries |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10027654/ https://www.ncbi.nlm.nih.gov/pubmed/36869744 http://dx.doi.org/10.1093/molbev/msad052 |
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