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Evaluation of transcutaneous near-infrared spectroscopy for early detection of cardiac arrest in an animal model
Sudden cardiac arrest (SCA) is a leading cause of mortality worldwide. The SCA-to-resuscitation interval is a key determinant of patient outcomes, highlighting the clinical need for reliable and timely detection of SCA. Near-infrared spectroscopy (NIRS), a non-invasive optical technique, may have ut...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10027843/ https://www.ncbi.nlm.nih.gov/pubmed/36941315 http://dx.doi.org/10.1038/s41598-023-31637-1 |
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author | Raschdorf, Katharina Mohseni, Arman Hogle, Kaavya Cheung, Amanda So, Kitty Manouchehri, Neda Khalili, Mahsa Lingawi, Saud Grunau, Brian Kuo, Calvin Christenson, Jim Shadgan, Babak |
author_facet | Raschdorf, Katharina Mohseni, Arman Hogle, Kaavya Cheung, Amanda So, Kitty Manouchehri, Neda Khalili, Mahsa Lingawi, Saud Grunau, Brian Kuo, Calvin Christenson, Jim Shadgan, Babak |
author_sort | Raschdorf, Katharina |
collection | PubMed |
description | Sudden cardiac arrest (SCA) is a leading cause of mortality worldwide. The SCA-to-resuscitation interval is a key determinant of patient outcomes, highlighting the clinical need for reliable and timely detection of SCA. Near-infrared spectroscopy (NIRS), a non-invasive optical technique, may have utility for this application. We investigated transcutaneous NIRS as a method to detect pentobarbital-induced changes during cardiac arrest in eight Yucatan miniature pigs. NIRS measurements during cardiac arrest were compared to invasively acquired carotid blood pressure and partial oxygen pressure (PO(2)) of spinal cord tissues. We observed statistically significant decreases in mean arterial pressure (MAP) 64.68 mmHg ± 13.08, p < 0.0001), spinal cord PO(2) (38.16 mmHg ± 20.04, p = 0.0028), and NIRS-derived tissue oxygen saturation (TSI%) (14.50% ± 3.80, p < 0.0001) from baseline to 5 min after pentobarbital administration. Euthanasia-to-first change in hemodynamics for MAP and TSI (%) were similar [MAP (10.43 ± 4.73 s) vs TSI (%) (12.04 ± 1.85 s), p = 0.3714]. No significant difference was detected between NIRS and blood pressure-derived pulse rates during baseline periods (p > 0.99) and following pentobarbital administration (p = 0.97). Transcutaneous NIRS demonstrated the potential to identify rapid hemodynamic changes due to cardiac arrest in periods similar to invasive indices. We conclude that transcutaneous NIRS monitoring may present a novel, non-invasive approach for SCA detection, which warrants further investigation. |
format | Online Article Text |
id | pubmed-10027843 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-100278432023-03-22 Evaluation of transcutaneous near-infrared spectroscopy for early detection of cardiac arrest in an animal model Raschdorf, Katharina Mohseni, Arman Hogle, Kaavya Cheung, Amanda So, Kitty Manouchehri, Neda Khalili, Mahsa Lingawi, Saud Grunau, Brian Kuo, Calvin Christenson, Jim Shadgan, Babak Sci Rep Article Sudden cardiac arrest (SCA) is a leading cause of mortality worldwide. The SCA-to-resuscitation interval is a key determinant of patient outcomes, highlighting the clinical need for reliable and timely detection of SCA. Near-infrared spectroscopy (NIRS), a non-invasive optical technique, may have utility for this application. We investigated transcutaneous NIRS as a method to detect pentobarbital-induced changes during cardiac arrest in eight Yucatan miniature pigs. NIRS measurements during cardiac arrest were compared to invasively acquired carotid blood pressure and partial oxygen pressure (PO(2)) of spinal cord tissues. We observed statistically significant decreases in mean arterial pressure (MAP) 64.68 mmHg ± 13.08, p < 0.0001), spinal cord PO(2) (38.16 mmHg ± 20.04, p = 0.0028), and NIRS-derived tissue oxygen saturation (TSI%) (14.50% ± 3.80, p < 0.0001) from baseline to 5 min after pentobarbital administration. Euthanasia-to-first change in hemodynamics for MAP and TSI (%) were similar [MAP (10.43 ± 4.73 s) vs TSI (%) (12.04 ± 1.85 s), p = 0.3714]. No significant difference was detected between NIRS and blood pressure-derived pulse rates during baseline periods (p > 0.99) and following pentobarbital administration (p = 0.97). Transcutaneous NIRS demonstrated the potential to identify rapid hemodynamic changes due to cardiac arrest in periods similar to invasive indices. We conclude that transcutaneous NIRS monitoring may present a novel, non-invasive approach for SCA detection, which warrants further investigation. Nature Publishing Group UK 2023-03-20 /pmc/articles/PMC10027843/ /pubmed/36941315 http://dx.doi.org/10.1038/s41598-023-31637-1 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Raschdorf, Katharina Mohseni, Arman Hogle, Kaavya Cheung, Amanda So, Kitty Manouchehri, Neda Khalili, Mahsa Lingawi, Saud Grunau, Brian Kuo, Calvin Christenson, Jim Shadgan, Babak Evaluation of transcutaneous near-infrared spectroscopy for early detection of cardiac arrest in an animal model |
title | Evaluation of transcutaneous near-infrared spectroscopy for early detection of cardiac arrest in an animal model |
title_full | Evaluation of transcutaneous near-infrared spectroscopy for early detection of cardiac arrest in an animal model |
title_fullStr | Evaluation of transcutaneous near-infrared spectroscopy for early detection of cardiac arrest in an animal model |
title_full_unstemmed | Evaluation of transcutaneous near-infrared spectroscopy for early detection of cardiac arrest in an animal model |
title_short | Evaluation of transcutaneous near-infrared spectroscopy for early detection of cardiac arrest in an animal model |
title_sort | evaluation of transcutaneous near-infrared spectroscopy for early detection of cardiac arrest in an animal model |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10027843/ https://www.ncbi.nlm.nih.gov/pubmed/36941315 http://dx.doi.org/10.1038/s41598-023-31637-1 |
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