MDM2 inhibitors, nutlin-3a and navtemadelin, retain efficacy in human and mouse cancer cells cultured in hypoxia

Activation of p53 by small molecule MDM2 inhibitors can induce cell cycle arrest or death in p53 wildtype cancer cells. However, cancer cells exposed to hypoxia can develop resistance to other small molecules, such as chemotherapies, that activate p53. Here, we evaluated whether hypoxia could render...

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Detalles Bibliográficos
Autores principales: Lerma Clavero, Ada, Boqvist, Paula Lafqvist, Ingelshed, Katrine, Bosdotter, Cecilia, Sedimbi, Saikiran, Jiang, Long, Wermeling, Fredrik, Vojtesek, Borivoj, Lane, David P., Kannan, Pavitra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10027891/
https://www.ncbi.nlm.nih.gov/pubmed/36941277
http://dx.doi.org/10.1038/s41598-023-31484-0

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