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Structure-based design and characterization of Parkin-activating mutations

Autosomal recessive mutations in the Parkin gene cause Parkinson’s disease. Parkin encodes an ubiquitin E3 ligase that functions together with the kinase PINK1 in a mitochondrial quality control pathway. Parkin exists in an inactive conformation mediated by autoinhibitory domain interfaces. Thus, Pa...

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Detalles Bibliográficos
Autores principales:	Stevens, Michael U, Croteau, Nathalie, Eldeeb, Mohamed A, Antico, Odetta, Zeng, Zhi Wei, Toth, Rachel, Durcan, Thomas M, Springer, Wolfdieter, Fon, Edward A, Muqit, Miratul MK, Trempe, Jean-François
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Life Science Alliance LLC 2023
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10027901/ https://www.ncbi.nlm.nih.gov/pubmed/36941054 http://dx.doi.org/10.26508/lsa.202201419

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