Cargando…

Loss of CD28 expression associates with severe T-cell exhaustion in acute myeloid leukemia

INTRODUCTION: Despite accumulated evidence in T-cell exhaustion in acute myeloid leukemia (AML), the immunotherapeutic targeting exhausted T cells such as programmed cell death protein 1 (PD-1) blockade in AML failed to achieve satisfying efficacy. Characteristics of exhausted T cells in AML remaine...

Descripción completa

Detalles Bibliográficos
Autores principales:	Huang, Yueting, Zheng, Huijian, Zhu, Yuwen, Hong, Yan, Zha, Jie, Lin, Zhijuan, Li, Zhifeng, Wang, Caiyan, Fang, Zhihong, Yu, Xingxing, Liu, Long, Xu, Bing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10027902/ https://www.ncbi.nlm.nih.gov/pubmed/36960073 http://dx.doi.org/10.3389/fimmu.2023.1139517

Ejemplares similares

CD26(low)PD-1(+) CD8 T cells are terminally exhausted and associated with leukemia progression in acute myeloid leukemia
por: Zhou, Huarong, et al.
Publicado: (2023)

CD8(+) T Cell Exhaustion in Cancer
por: Dolina, Joseph S., et al.
Publicado: (2021)

CD28(−) and CD28(low)CD8(+) Regulatory T Cells: Of Mice and Men
por: Vuddamalay, Yirajen, et al.
Publicado: (2017)

Bcl-2 inhibition combined with PPARα activation synergistically targets leukemic stem cell-like cells in acute myeloid leukemia
por: Xie, Chendi, et al.
Publicado: (2023)

Dynamic Network Biomarker of Pre-Exhausted CD8(+) T Cells Contributed to T Cell Exhaustion in Colorectal Cancer
por: Hu, Jiaqi, et al.
Publicado: (2021)

The CD28-Transmembrane Domain Mediates Chimeric Antigen Receptor Heterodimerization With CD28
por: Muller, Yannick D., et al.
Publicado: (2021)

Targeted CD7 CAR T-cells for treatment of T-Lymphocyte leukemia and lymphoma and acute myeloid leukemia: recent advances
por: Liu, Jile, et al.
Publicado: (2023)

Helpless Priming Sends CD8(+) T Cells on the Road to Exhaustion
por: Busselaar, Julia, et al.
Publicado: (2020)

Hypoxia Supports Differentiation of Terminally Exhausted CD8 T Cells
por: Bannoud, Nadia, et al.
Publicado: (2021)

Strategies to reinvigorate exhausted CD8(+) T cells in tumor microenvironment
por: Guan, Qianting, et al.
Publicado: (2023)

Landscapes and mechanisms of CD8(+) T cell exhaustion in gastrointestinal cancer
por: Ding, Jia-Tong, et al.
Publicado: (2023)

Elevated Exhaustion Levels of NK and CD8(+) T Cells as Indicators for Progression and Prognosis of COVID-19 Disease
por: Li, Mingyue, et al.
Publicado: (2020)

Preclinical evaluation of CD70-specific CAR T cells targeting acute myeloid leukemia
por: Wu, Gongqiang, et al.
Publicado: (2023)

NKT-Like (CD3+CD56+) Cells in Chronic Myeloid Leukemia Patients Treated With Tyrosine Kinase Inhibitors
por: Almeida, Jani-Sofia, et al.
Publicado: (2019)

CD38 marks the exhausted CD8(+) tissue-resident memory T cells in hepatocellular carcinoma
por: Reolo, Marie J. Y., et al.
Publicado: (2023)

The development of CD8 T-cell exhaustion heterogeneity and the therapeutic potentials in cancer
por: Zhang, Junfeng, et al.
Publicado: (2023)

Ibrutinib directly reduces CD8+T cell exhaustion independent of BTK
por: Li, Ling, et al.
Publicado: (2023)

Divide, Conquer, and Sense: CD8(+)CD28(−) T Cells in Perspective
por: Arosa, Fernando A., et al.
Publicado: (2017)

High Levels of Eomes Promote Exhaustion of Anti-tumor CD8(+) T Cells
por: Li, Jing, et al.
Publicado: (2018)

The Chronic Stages of Bovine Fasciola hepatica Are Dominated by CD4 T-Cell Exhaustion
por: Sachdev, Divya, et al.
Publicado: (2017)

Exhausted CD8+T Cells in the Tumor Immune Microenvironment: New Pathways to Therapy
por: Jiang, Weiqin, et al.
Publicado: (2021)

Exhaust the exhausters: Targeting regulatory T cells in the tumor microenvironment
por: McRitchie, Bayley R., et al.
Publicado: (2022)

High CD8(+)tumor-infiltrating lymphocytes indicate severe exhaustion and poor prognosis in angioimmunoblastic T-cell lymphoma
por: Zhu, Qiqi, et al.
Publicado: (2023)

The cytokine network in acute myeloid leukemia
por: Luciano, Michela, et al.
Publicado: (2022)

CD28 Signaling Drives Notch Ligand Expression on CD4 T Cells
por: Mitra, Ankita, et al.
Publicado: (2020)

Engineering tandem CD33xCD146 CAR CIK (cytokine-induced killer) cells to target the acute myeloid leukemia niche
por: Alberti, Gaia, et al.
Publicado: (2023)

CD28-signaling can be partially compensated in CD28-knockout mice but is essential for virus elimination in a murine model of multiple sclerosis
por: Hülskötter, Kirsten, et al.
Publicado: (2023)

Demethylating therapy increases cytotoxicity of CD44v6 CAR-T cells against acute myeloid leukemia
por: Tang, Ling, et al.
Publicado: (2023)

Exhaustion of the CD8(+) T Cell Compartment in Patients with Mutations in Phosphoinositide 3-Kinase Delta
por: Wentink, Marjolein W. J., et al.
Publicado: (2018)

Recurrent Sepsis Exacerbates CD4(+) T Cell Exhaustion and Decreases Antiviral Immune Responses
por: He, Wanxue, et al.
Publicado: (2021)

The Road Less Taken: Less Appreciated Pathways for Manipulating CD8(+) T Cell Exhaustion
por: Pichler, Andrea C., et al.
Publicado: (2022)

Establishment and validation of exhausted CD8+ T cell feature as a prognostic model of HCC
por: Shi, Jihang, et al.
Publicado: (2023)

Clonal Exhaustion as a Mechanism to Protect Against Severe Immunopathology and Death from an Overwhelming CD8 T Cell Response
por: Cornberg, Markus, et al.
Publicado: (2013)

Long-Term Ibrutinib Therapy Reverses CD8(+) T Cell Exhaustion in B Cell Chronic Lymphocytic Leukaemia
por: Parry, Helen M., et al.
Publicado: (2019)

Comprehensive analysis of the immune pattern of T cell subsets in chronic myeloid leukemia before and after TKI treatment
por: Yao, Danlin, et al.
Publicado: (2023)

Case report: CD38-directed CAR-T cell therapy: A novel immunotherapy targeting CD38- positive blasts overcomes TKI and chemotherapy resistance of myeloid chronic myeloid leukemia in blastic phase
por: Cui, Qingya, et al.
Publicado: (2022)

Dendritic Cell-Based Immunotherapy for Myeloid Leukemias
por: Schürch, Christian M., et al.
Publicado: (2013)

Identification and validation of a novel CD8+ T cell-associated prognostic model based on ferroptosis in acute myeloid leukemia
por: Jiang, Ge, et al.
Publicado: (2023)

The CD28 Transmembrane Domain Contains an Essential Dimerization Motif
por: Leddon, Scott A., et al.
Publicado: (2020)

CD28 Superagonist Shock and Blockage of Motogenic T Cell Cascade
por: Sundqvist, Karl-Gösta
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_sq20gchg1ov0af9u9kfs4mtdi0