Prediction of in vivo prenatal chlorpyrifos exposure leading to developmental neurotoxicity in humans based on in vitro toxicity data by quantitative in vitro–in vivo extrapolation

Introduction: Epidemiological studies in children suggested that in utero exposure to chlorpyrifos (CPF), an organophosphate insecticide, may cause developmental neurotoxicity (DNT). We applied quantitative in vitro–in vivo extrapolation (QIVIVE) based on in vitro concentration and non-choline ester...

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Detalles Bibliográficos
Autores principales: Algharably, Engi Abdelhady, Di Consiglio, Emma, Testai, Emanuela, Pistollato, Francesca, Bal-Price, Anna, Najjar, Abdulkarim, Kreutz, Reinhold, Gundert-Remy, Ursula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10027916/
https://www.ncbi.nlm.nih.gov/pubmed/36959852
http://dx.doi.org/10.3389/fphar.2023.1136174

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