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Physiologically based pharmacokinetic-pharmacodynamic evaluation of meropenem in CKD and hemodialysis individuals

Objective: Chronic kidney disease (CKD) has significant effects on renal clearance of drugs. The application of antibiotics in CKD patients to achieve the desired therapeutic effect is challenging. This study aims to determine meropenem plasma exposure in the CKD population and further investigate o...

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Detalles Bibliográficos
Autores principales:	Deng, Guoliang, Yang, Fan, Sun, Ning, Liang, Danhong, Cen, Anfen, Zhang, Chen, Ni, Suiqin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10027930/ https://www.ncbi.nlm.nih.gov/pubmed/36959849 http://dx.doi.org/10.3389/fphar.2023.1126714

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