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Brothers and sisters of childhood acute leukemia survivors: Their long‐term quality of life and its determinants

BACKGROUND: Childhood cancer confront the whole family with a traumatic event. Because brothers and sisters may encounter emotional problems that can remain for a long time and that only few studies have assessed their long‐term outcome, our present objectives were to describe the long‐term quality...

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Autores principales: Faust, Cindy, Auquier, Pascal, Hamidou, Zeinab, Bertrand, Yves, Tabone, Marie‐Dominique, Ansoborlo, Sophie, Baruchel, André, Gandemer, Virginie, Dalle, Jean‐Hugues, Chastagner, Pascal, Kanold, Justyna, Poirée, Maryline, Sirvent, Nicolas, Plat, Geneviève, Pellier, Isabelle, Michel, Gérard, Berbis, Julie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10028038/
https://www.ncbi.nlm.nih.gov/pubmed/36266927
http://dx.doi.org/10.1002/cam4.5355
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author Faust, Cindy
Auquier, Pascal
Hamidou, Zeinab
Bertrand, Yves
Tabone, Marie‐Dominique
Ansoborlo, Sophie
Baruchel, André
Gandemer, Virginie
Dalle, Jean‐Hugues
Chastagner, Pascal
Kanold, Justyna
Poirée, Maryline
Sirvent, Nicolas
Plat, Geneviève
Pellier, Isabelle
Michel, Gérard
Berbis, Julie
author_facet Faust, Cindy
Auquier, Pascal
Hamidou, Zeinab
Bertrand, Yves
Tabone, Marie‐Dominique
Ansoborlo, Sophie
Baruchel, André
Gandemer, Virginie
Dalle, Jean‐Hugues
Chastagner, Pascal
Kanold, Justyna
Poirée, Maryline
Sirvent, Nicolas
Plat, Geneviève
Pellier, Isabelle
Michel, Gérard
Berbis, Julie
author_sort Faust, Cindy
collection PubMed
description BACKGROUND: Childhood cancer confront the whole family with a traumatic event. Because brothers and sisters may encounter emotional problems that can remain for a long time and that only few studies have assessed their long‐term outcome, our present objectives were to describe the long‐term quality of life (QoL) of childhood leukemia survivors' siblings and to explore its determinant. METHODS: Brothers and sisters (from 8‐year‐old) of survivors included in the French LEA Cohort completed a QoL questionnaire (according to their age). Scores were compared with those reported by age‐ and gender‐matched French general population and by survivors. Using a clustering method, siblings were categorized into 3 groups depending on their level of QoL's scores and factors likely to be linked with these clusters were explored with multivariate analyses. RESULTS: We included 689 brothers and sisters (313 minors, 376 adults) and the mean time from diagnosis was 13.2 ± 6.6 years. Minor siblings reported higher QoL scores than general population (p < 0.001), but a lower score for relationship with family than survivors (p < 0.001). In adult siblings, Mental Component Summary score was lower than general population (p < 0.001). Level of siblings' QoL was linked with female gender, but no association was found with cancer‐related factors. CONCLUSION: Brothers and sisters expressed a divergent perception of their long‐term QoL depending on their age. To minimize the impact from childhood to adulthood, long‐term attention should also be paid to siblings, often referred as “forgotten children”.
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spelling pubmed-100280382023-03-22 Brothers and sisters of childhood acute leukemia survivors: Their long‐term quality of life and its determinants Faust, Cindy Auquier, Pascal Hamidou, Zeinab Bertrand, Yves Tabone, Marie‐Dominique Ansoborlo, Sophie Baruchel, André Gandemer, Virginie Dalle, Jean‐Hugues Chastagner, Pascal Kanold, Justyna Poirée, Maryline Sirvent, Nicolas Plat, Geneviève Pellier, Isabelle Michel, Gérard Berbis, Julie Cancer Med RESEARCH ARTICLES BACKGROUND: Childhood cancer confront the whole family with a traumatic event. Because brothers and sisters may encounter emotional problems that can remain for a long time and that only few studies have assessed their long‐term outcome, our present objectives were to describe the long‐term quality of life (QoL) of childhood leukemia survivors' siblings and to explore its determinant. METHODS: Brothers and sisters (from 8‐year‐old) of survivors included in the French LEA Cohort completed a QoL questionnaire (according to their age). Scores were compared with those reported by age‐ and gender‐matched French general population and by survivors. Using a clustering method, siblings were categorized into 3 groups depending on their level of QoL's scores and factors likely to be linked with these clusters were explored with multivariate analyses. RESULTS: We included 689 brothers and sisters (313 minors, 376 adults) and the mean time from diagnosis was 13.2 ± 6.6 years. Minor siblings reported higher QoL scores than general population (p < 0.001), but a lower score for relationship with family than survivors (p < 0.001). In adult siblings, Mental Component Summary score was lower than general population (p < 0.001). Level of siblings' QoL was linked with female gender, but no association was found with cancer‐related factors. CONCLUSION: Brothers and sisters expressed a divergent perception of their long‐term QoL depending on their age. To minimize the impact from childhood to adulthood, long‐term attention should also be paid to siblings, often referred as “forgotten children”. John Wiley and Sons Inc. 2022-10-20 /pmc/articles/PMC10028038/ /pubmed/36266927 http://dx.doi.org/10.1002/cam4.5355 Text en © 2022 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle RESEARCH ARTICLES
Faust, Cindy
Auquier, Pascal
Hamidou, Zeinab
Bertrand, Yves
Tabone, Marie‐Dominique
Ansoborlo, Sophie
Baruchel, André
Gandemer, Virginie
Dalle, Jean‐Hugues
Chastagner, Pascal
Kanold, Justyna
Poirée, Maryline
Sirvent, Nicolas
Plat, Geneviève
Pellier, Isabelle
Michel, Gérard
Berbis, Julie
Brothers and sisters of childhood acute leukemia survivors: Their long‐term quality of life and its determinants
title Brothers and sisters of childhood acute leukemia survivors: Their long‐term quality of life and its determinants
title_full Brothers and sisters of childhood acute leukemia survivors: Their long‐term quality of life and its determinants
title_fullStr Brothers and sisters of childhood acute leukemia survivors: Their long‐term quality of life and its determinants
title_full_unstemmed Brothers and sisters of childhood acute leukemia survivors: Their long‐term quality of life and its determinants
title_short Brothers and sisters of childhood acute leukemia survivors: Their long‐term quality of life and its determinants
title_sort brothers and sisters of childhood acute leukemia survivors: their long‐term quality of life and its determinants
topic RESEARCH ARTICLES
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10028038/
https://www.ncbi.nlm.nih.gov/pubmed/36266927
http://dx.doi.org/10.1002/cam4.5355
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