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Survival trends for patients with retinoblastoma between 2000 and 2018: What has changed?

INTRODUCTION: Retinoblastoma (RB) is the most common primary intraocular cancer of childhood. Over the last few decades, a variety of techniques and treatment modalities emerged that improved the survival and ocular salvage rate of patients with RB. We investigated the relative survival trends of pa...

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Autores principales: Abdelazeem, Basel, Abbas, Kirellos Said, Shehata, Joseph, El‐Shahat, Nahla Ahmed, Eltaras, Mennatullah Mohamed, Qaddoumi, Ibrahim, Alfaar, Ahmad Samir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10028055/
https://www.ncbi.nlm.nih.gov/pubmed/36479934
http://dx.doi.org/10.1002/cam4.5406
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author Abdelazeem, Basel
Abbas, Kirellos Said
Shehata, Joseph
El‐Shahat, Nahla Ahmed
Eltaras, Mennatullah Mohamed
Qaddoumi, Ibrahim
Alfaar, Ahmad Samir
author_facet Abdelazeem, Basel
Abbas, Kirellos Said
Shehata, Joseph
El‐Shahat, Nahla Ahmed
Eltaras, Mennatullah Mohamed
Qaddoumi, Ibrahim
Alfaar, Ahmad Samir
author_sort Abdelazeem, Basel
collection PubMed
description INTRODUCTION: Retinoblastoma (RB) is the most common primary intraocular cancer of childhood. Over the last few decades, a variety of techniques and treatment modalities emerged that improved the survival and ocular salvage rate of patients with RB. We investigated the relative survival trends of patients with RB from 2000 to 2018 by using the Surveillance, Epidemiology, and End Results (SEER) database. DESIGN: Retrospective database review. METHODS: We extracted data from SEER 18 from 2000 to 2018. All patients with clinically diagnosed RB during the study period were included. We utilized SEER*Stat 8.3.9 and JPSurv software to estimate relative 5‐ and 10‐year survival rates and trends and generated descriptive analyses with IBM SPSS. MAIN OUTCOME MEASURES: Patient survival rates at 5‐ and 10‐year after RB diagnosis. RESULTS: RB was diagnosed in 1479 patients within the SEER 18 Program during our study period. The cohort comprised 776 (52.5%) males, 615 (41.6%) non‐Hispanic whites, 487(32.9%) Hispanics, 1030 (69.6%) patients with unilateral disease, and 1087 (73.5%) patients with localized disease. Relative survival trends at 5‐ and 10‐year significantly declined over the study periods (−0.42%, and −0.50% annually, respectively) but the decline was not significant in unilateral and bilateral RB cases separately. CONCLUSIONS: Five‐ and ten‐year relative survival trends declined from 2000 to 2018 and were significantly decreasing. Further studies that include more patients are needed to identify the factors contributing to reduced survival of patients with RB over time.
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spelling pubmed-100280552023-03-22 Survival trends for patients with retinoblastoma between 2000 and 2018: What has changed? Abdelazeem, Basel Abbas, Kirellos Said Shehata, Joseph El‐Shahat, Nahla Ahmed Eltaras, Mennatullah Mohamed Qaddoumi, Ibrahim Alfaar, Ahmad Samir Cancer Med RESEARCH ARTICLES INTRODUCTION: Retinoblastoma (RB) is the most common primary intraocular cancer of childhood. Over the last few decades, a variety of techniques and treatment modalities emerged that improved the survival and ocular salvage rate of patients with RB. We investigated the relative survival trends of patients with RB from 2000 to 2018 by using the Surveillance, Epidemiology, and End Results (SEER) database. DESIGN: Retrospective database review. METHODS: We extracted data from SEER 18 from 2000 to 2018. All patients with clinically diagnosed RB during the study period were included. We utilized SEER*Stat 8.3.9 and JPSurv software to estimate relative 5‐ and 10‐year survival rates and trends and generated descriptive analyses with IBM SPSS. MAIN OUTCOME MEASURES: Patient survival rates at 5‐ and 10‐year after RB diagnosis. RESULTS: RB was diagnosed in 1479 patients within the SEER 18 Program during our study period. The cohort comprised 776 (52.5%) males, 615 (41.6%) non‐Hispanic whites, 487(32.9%) Hispanics, 1030 (69.6%) patients with unilateral disease, and 1087 (73.5%) patients with localized disease. Relative survival trends at 5‐ and 10‐year significantly declined over the study periods (−0.42%, and −0.50% annually, respectively) but the decline was not significant in unilateral and bilateral RB cases separately. CONCLUSIONS: Five‐ and ten‐year relative survival trends declined from 2000 to 2018 and were significantly decreasing. Further studies that include more patients are needed to identify the factors contributing to reduced survival of patients with RB over time. John Wiley and Sons Inc. 2022-12-08 /pmc/articles/PMC10028055/ /pubmed/36479934 http://dx.doi.org/10.1002/cam4.5406 Text en © 2022 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle RESEARCH ARTICLES
Abdelazeem, Basel
Abbas, Kirellos Said
Shehata, Joseph
El‐Shahat, Nahla Ahmed
Eltaras, Mennatullah Mohamed
Qaddoumi, Ibrahim
Alfaar, Ahmad Samir
Survival trends for patients with retinoblastoma between 2000 and 2018: What has changed?
title Survival trends for patients with retinoblastoma between 2000 and 2018: What has changed?
title_full Survival trends for patients with retinoblastoma between 2000 and 2018: What has changed?
title_fullStr Survival trends for patients with retinoblastoma between 2000 and 2018: What has changed?
title_full_unstemmed Survival trends for patients with retinoblastoma between 2000 and 2018: What has changed?
title_short Survival trends for patients with retinoblastoma between 2000 and 2018: What has changed?
title_sort survival trends for patients with retinoblastoma between 2000 and 2018: what has changed?
topic RESEARCH ARTICLES
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10028055/
https://www.ncbi.nlm.nih.gov/pubmed/36479934
http://dx.doi.org/10.1002/cam4.5406
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