Role of microbiota and microbiota‐derived short‐chain fatty acids in PDAC

Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive lethal diseases among other cancer types. Gut microbiome and its metabolic regulation play a crucial role in PDAC. Metabolic regulation in the gut is a complex process that involves microbiome and microbiome‐derived short‐chain fa...

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Autores principales: Temel, Hülya Yılmaz, Kaymak, Öznur, Kaplan, Seren, Bahcivanci, Basak, Gkoutos, Georgios V., Acharjee, Animesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
REVIEWS
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10028056/
https://www.ncbi.nlm.nih.gov/pubmed/36205023
http://dx.doi.org/10.1002/cam4.5323
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author Temel, Hülya Yılmaz
Kaymak, Öznur
Kaplan, Seren
Bahcivanci, Basak
Gkoutos, Georgios V.
Acharjee, Animesh
author_facet Temel, Hülya Yılmaz
Kaymak, Öznur
Kaplan, Seren
Bahcivanci, Basak
Gkoutos, Georgios V.
Acharjee, Animesh
author_sort Temel, Hülya Yılmaz
collection PubMed
description Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive lethal diseases among other cancer types. Gut microbiome and its metabolic regulation play a crucial role in PDAC. Metabolic regulation in the gut is a complex process that involves microbiome and microbiome‐derived short‐chain fatty acids (SCFAs). SCFAs regulate inflammation, as well as lipid and glucose metabolism, through different pathways. This review aims to summarize recent developments in PDAC in the context of gut and oral microbiota and their associations with short‐chain fatty acid (SCFA). In addition to this, we discuss possible therapeutic applications using microbiota in PDAC.
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spelling pubmed-100280562023-03-22 Role of microbiota and microbiota‐derived short‐chain fatty acids in PDAC Temel, Hülya Yılmaz Kaymak, Öznur Kaplan, Seren Bahcivanci, Basak Gkoutos, Georgios V. Acharjee, Animesh Cancer Med REVIEWS Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive lethal diseases among other cancer types. Gut microbiome and its metabolic regulation play a crucial role in PDAC. Metabolic regulation in the gut is a complex process that involves microbiome and microbiome‐derived short‐chain fatty acids (SCFAs). SCFAs regulate inflammation, as well as lipid and glucose metabolism, through different pathways. This review aims to summarize recent developments in PDAC in the context of gut and oral microbiota and their associations with short‐chain fatty acid (SCFA). In addition to this, we discuss possible therapeutic applications using microbiota in PDAC. John Wiley and Sons Inc. 2022-10-07 /pmc/articles/PMC10028056/ /pubmed/36205023 http://dx.doi.org/10.1002/cam4.5323 Text en © 2022 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle REVIEWS
Temel, Hülya Yılmaz
Kaymak, Öznur
Kaplan, Seren
Bahcivanci, Basak
Gkoutos, Georgios V.
Acharjee, Animesh
Role of microbiota and microbiota‐derived short‐chain fatty acids in PDAC
title Role of microbiota and microbiota‐derived short‐chain fatty acids in PDAC
title_full Role of microbiota and microbiota‐derived short‐chain fatty acids in PDAC
title_fullStr Role of microbiota and microbiota‐derived short‐chain fatty acids in PDAC
title_full_unstemmed Role of microbiota and microbiota‐derived short‐chain fatty acids in PDAC
title_short Role of microbiota and microbiota‐derived short‐chain fatty acids in PDAC
title_sort role of microbiota and microbiota‐derived short‐chain fatty acids in pdac
topic REVIEWS
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10028056/
https://www.ncbi.nlm.nih.gov/pubmed/36205023
http://dx.doi.org/10.1002/cam4.5323
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