Cargando…
Inhibition of XPO1 impairs cholangiocarcinoma cell proliferation by triggering p53 intranuclear accumulation
BACKGROUND: XPO1 mediates the nuclear export of several proteins, mainly tumor suppressors. KPT‐330 (Selinexor) is a selective inhibitor of XPO1 that has demonstrated good therapeutic effects in hematologic cancers. METHODS: We used TCGA and GTEx pan‐cancer database to evaluate XPO1 mRNA expression...
Autores principales: | Zhao, Cheng, Ma, Ben, Yang, Zi‐yi, Li, Ou, Liu, Shi‐lei, Pan, Li‐jia, Gong, Wei, Dong, Ping, Shu, Yi‐jun |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10028126/ https://www.ncbi.nlm.nih.gov/pubmed/36200270 http://dx.doi.org/10.1002/cam4.5322 |
Ejemplares similares
-
Inhibition of XPO1 with KPT-330 induces autophagy-dependent apoptosis in gallbladder cancer by activating the p53/mTOR pathway
por: Zhao, Cheng, et al.
Publicado: (2022) -
Intranuclear accumulation of galectin-3 is an independent prognostic factor for patients with distal cholangiocarcinoma
por: Shimura, Tatsuo, et al.
Publicado: (2017) -
Extra- and intranuclear heat perception and triggering mechanisms in plants
por: Yang, Xiaolong, et al.
Publicado: (2023) -
XPO1 inhibitors represent a novel therapeutic option in Adult T-cell Leukemia, triggering p53-mediated caspase-dependent apoptosis
por: Boons, Eline, et al.
Publicado: (2021) -
Novel Small Molecule XPO1/CRM1 Inhibitors Induce Nuclear Accumulation of TP53, Phosphorylated MAPK and Apoptosis in Human Melanoma Cells
por: Yang, Jennifer, et al.
Publicado: (2014)