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Inhibition of XPO1 impairs cholangiocarcinoma cell proliferation by triggering p53 intranuclear accumulation

BACKGROUND: XPO1 mediates the nuclear export of several proteins, mainly tumor suppressors. KPT‐330 (Selinexor) is a selective inhibitor of XPO1 that has demonstrated good therapeutic effects in hematologic cancers. METHODS: We used TCGA and GTEx pan‐cancer database to evaluate XPO1 mRNA expression...

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Detalles Bibliográficos
Autores principales:	Zhao, Cheng, Ma, Ben, Yang, Zi‐yi, Li, Ou, Liu, Shi‐lei, Pan, Li‐jia, Gong, Wei, Dong, Ping, Shu, Yi‐jun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	RESEARCH ARTICLES
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10028126/ https://www.ncbi.nlm.nih.gov/pubmed/36200270 http://dx.doi.org/10.1002/cam4.5322

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