CARD11 gain-of-function mutation drives cell-autonomous accumulation of PD-1(+) ICOS(high) activated T cells, T-follicular, T-regulatory and T-follicular regulatory cells

INTRODUCTION: Germline CARD11 gain-of-function (GOF) mutations cause B cell Expansion with NF-κB and T cell Anergy (BENTA) disease, whilst somatic GOF CARD11 mutations recur in diffuse large B cell lymphoma (DLBCL) and in up to 30% of the peripheral T cell lymphomas (PTCL) adult T cell leukemia/lymp...

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Detalles Bibliográficos
Autores principales: Masle-Farquhar, Etienne, Jeelall, Yogesh, White, Jacqueline, Bier, Julia, Deenick, Elissa K., Brink, Robert, Horikawa, Keisuke, Goodnow, Christopher Carl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10028194/
https://www.ncbi.nlm.nih.gov/pubmed/36960072
http://dx.doi.org/10.3389/fimmu.2023.1095257

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10028194/
https://www.ncbi.nlm.nih.gov/pubmed/36960072
http://dx.doi.org/10.3389/fimmu.2023.1095257

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