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CARD11 gain-of-function mutation drives cell-autonomous accumulation of PD-1(+) ICOS(high) activated T cells, T-follicular, T-regulatory and T-follicular regulatory cells
INTRODUCTION: Germline CARD11 gain-of-function (GOF) mutations cause B cell Expansion with NF-κB and T cell Anergy (BENTA) disease, whilst somatic GOF CARD11 mutations recur in diffuse large B cell lymphoma (DLBCL) and in up to 30% of the peripheral T cell lymphomas (PTCL) adult T cell leukemia/lymp...
Autores principales: | Masle-Farquhar, Etienne, Jeelall, Yogesh, White, Jacqueline, Bier, Julia, Deenick, Elissa K., Brink, Robert, Horikawa, Keisuke, Goodnow, Christopher Carl |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10028194/ https://www.ncbi.nlm.nih.gov/pubmed/36960072 http://dx.doi.org/10.3389/fimmu.2023.1095257 |
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