PD-1 and CTLA-4 exert additive control of effector regulatory T cells at homeostasis

At homeostasis, a substantial proportion of Foxp3(+) T regulatory cells (T(regs)) have an activated phenotype associated with enhanced TCR signals and these effector T(reg) cells (eT(regs)) co-express elevated levels of PD-1 and CTLA-4. Short term in vivo blockade of the PD-1 or CTLA-4 pathways resu...

Descripción completa

Detalles Bibliográficos
Autores principales: Pereira, Joseph A., Lanzar, Zachary, Clark, Joseph T., Hart, Andrew P., Douglas, Bonnie B., Shallberg, Lindsey, O’Dea, Keenan, Christian, David A., Hunter, Christopher A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10028286/
https://www.ncbi.nlm.nih.gov/pubmed/36960049
http://dx.doi.org/10.3389/fimmu.2023.997376

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10028286/
https://www.ncbi.nlm.nih.gov/pubmed/36960049
http://dx.doi.org/10.3389/fimmu.2023.997376

Ejemplares similares