Coronavirus Disease 2019 Management Strategies in Solid Organ Transplant Recipients

Solid organ transplant recipients are at high risk of severe coronavirus disease-2019 (COVID-19). If left untreated, it results in high rates of hospitalization, intensive care unit admission and death. Early diagnosis of COVID-19 is essential to ensure the early administration of therapeutics. Trea...

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Detalles Bibliográficos
Autores principales: Mendoza, Maria Alejandra, Razonable, Raymund R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10028355/
https://www.ncbi.nlm.nih.gov/pubmed/37142512
http://dx.doi.org/10.1016/j.idc.2023.03.003
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author Mendoza, Maria Alejandra
Razonable, Raymund R.
author_facet Mendoza, Maria Alejandra
Razonable, Raymund R.
author_sort Mendoza, Maria Alejandra
collection PubMed
description Solid organ transplant recipients are at high risk of severe coronavirus disease-2019 (COVID-19). If left untreated, it results in high rates of hospitalization, intensive care unit admission and death. Early diagnosis of COVID-19 is essential to ensure the early administration of therapeutics. Treatment of mild-to-moderate COVID-19 with remdesivir, ritonavir-boosted nirmatrelvir, or an anti-spike neutralizing monoclonal antibody may prevent progression to severe and critical COVID-19. Among patients with severe and critical COVID-19, treatment with intravenous remdesivir and immunomodulation is recommended. This review article discusses strategies in the management of solid organ transplant recipients with COVID-19.
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spelling pubmed-100283552023-03-21 Coronavirus Disease 2019 Management Strategies in Solid Organ Transplant Recipients Mendoza, Maria Alejandra Razonable, Raymund R. Infect Dis Clin North Am Article Solid organ transplant recipients are at high risk of severe coronavirus disease-2019 (COVID-19). If left untreated, it results in high rates of hospitalization, intensive care unit admission and death. Early diagnosis of COVID-19 is essential to ensure the early administration of therapeutics. Treatment of mild-to-moderate COVID-19 with remdesivir, ritonavir-boosted nirmatrelvir, or an anti-spike neutralizing monoclonal antibody may prevent progression to severe and critical COVID-19. Among patients with severe and critical COVID-19, treatment with intravenous remdesivir and immunomodulation is recommended. This review article discusses strategies in the management of solid organ transplant recipients with COVID-19. Elsevier Inc. 2023-03-21 /pmc/articles/PMC10028355/ /pubmed/37142512 http://dx.doi.org/10.1016/j.idc.2023.03.003 Text en © 2023 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Mendoza, Maria Alejandra
Razonable, Raymund R.
Coronavirus Disease 2019 Management Strategies in Solid Organ Transplant Recipients
title Coronavirus Disease 2019 Management Strategies in Solid Organ Transplant Recipients
title_full Coronavirus Disease 2019 Management Strategies in Solid Organ Transplant Recipients
title_fullStr Coronavirus Disease 2019 Management Strategies in Solid Organ Transplant Recipients
title_full_unstemmed Coronavirus Disease 2019 Management Strategies in Solid Organ Transplant Recipients
title_short Coronavirus Disease 2019 Management Strategies in Solid Organ Transplant Recipients
title_sort coronavirus disease 2019 management strategies in solid organ transplant recipients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10028355/
https://www.ncbi.nlm.nih.gov/pubmed/37142512
http://dx.doi.org/10.1016/j.idc.2023.03.003
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