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Anti-obesity effect of collagen peptides obtained from Diplulmaris antarctica, a jellyfish of the Antarctic region

AIM: To investigate the ability of collagen peptides derived from a jellyfish of the Antarctic region (Diplulmaris antarctica) to prevent the development of obesity in rats fed a high-calorie diet. METHODS: Collagen peptides were produced by pepsin hydrolysis of jellyfish-derived collagen. The purit...

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Autores principales: Raksha, Nataliia, Halenova, Tetiana, Vovk, Tetiana, Kostyuk, Olexandra, Synelnyk, Tatyana, Andriichuk, Tatyana, Maievska, Tetiana, Savchuk, Olexiy, Ostapchenko, Ludmila
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Croatian Medical Schools 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10028559/
https://www.ncbi.nlm.nih.gov/pubmed/36864815
http://dx.doi.org/10.3325/cmj.2023.64.21
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author Raksha, Nataliia
Halenova, Tetiana
Vovk, Tetiana
Kostyuk, Olexandra
Synelnyk, Tatyana
Andriichuk, Tatyana
Maievska, Tetiana
Savchuk, Olexiy
Ostapchenko, Ludmila
author_facet Raksha, Nataliia
Halenova, Tetiana
Vovk, Tetiana
Kostyuk, Olexandra
Synelnyk, Tatyana
Andriichuk, Tatyana
Maievska, Tetiana
Savchuk, Olexiy
Ostapchenko, Ludmila
author_sort Raksha, Nataliia
collection PubMed
description AIM: To investigate the ability of collagen peptides derived from a jellyfish of the Antarctic region (Diplulmaris antarctica) to prevent the development of obesity in rats fed a high-calorie diet. METHODS: Collagen peptides were produced by pepsin hydrolysis of jellyfish-derived collagen. The purity of collagen and collagen peptides was confirmed by SDS-polyacrylamide gel electrophoresis. Rats were fed a high-calorie diet for ten weeks and were simultaneously orally administered collagen peptides (1 g per 1 kg of body weight every other day) starting from the fourth week. Body mass index (BMI), body weight gain, selected nutritional parameters, the key parameters associated with insulin resistance, and the level of oxidative stress markers were assessed. RESULTS: Compared with untreated obese rats, rats treated with hydrolyzed jellyfish collagen peptides had a decreased body weight gain and body mass index. They also had a decreased level of fasting blood glucose, glycated hemoglobin, insulin, lipid peroxidation products (conjugated dienes, Schiff bases), and oxidatively modified proteins, as well as a restored activity of superoxide dismutase.
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spelling pubmed-100285592023-03-22 Anti-obesity effect of collagen peptides obtained from Diplulmaris antarctica, a jellyfish of the Antarctic region Raksha, Nataliia Halenova, Tetiana Vovk, Tetiana Kostyuk, Olexandra Synelnyk, Tatyana Andriichuk, Tatyana Maievska, Tetiana Savchuk, Olexiy Ostapchenko, Ludmila Croat Med J Research Article AIM: To investigate the ability of collagen peptides derived from a jellyfish of the Antarctic region (Diplulmaris antarctica) to prevent the development of obesity in rats fed a high-calorie diet. METHODS: Collagen peptides were produced by pepsin hydrolysis of jellyfish-derived collagen. The purity of collagen and collagen peptides was confirmed by SDS-polyacrylamide gel electrophoresis. Rats were fed a high-calorie diet for ten weeks and were simultaneously orally administered collagen peptides (1 g per 1 kg of body weight every other day) starting from the fourth week. Body mass index (BMI), body weight gain, selected nutritional parameters, the key parameters associated with insulin resistance, and the level of oxidative stress markers were assessed. RESULTS: Compared with untreated obese rats, rats treated with hydrolyzed jellyfish collagen peptides had a decreased body weight gain and body mass index. They also had a decreased level of fasting blood glucose, glycated hemoglobin, insulin, lipid peroxidation products (conjugated dienes, Schiff bases), and oxidatively modified proteins, as well as a restored activity of superoxide dismutase. Croatian Medical Schools 2023-02 /pmc/articles/PMC10028559/ /pubmed/36864815 http://dx.doi.org/10.3325/cmj.2023.64.21 Text en Copyright © 2023 by the Croatian Medical Journal. All rights reserved. https://creativecommons.org/licenses/by/2.5/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Raksha, Nataliia
Halenova, Tetiana
Vovk, Tetiana
Kostyuk, Olexandra
Synelnyk, Tatyana
Andriichuk, Tatyana
Maievska, Tetiana
Savchuk, Olexiy
Ostapchenko, Ludmila
Anti-obesity effect of collagen peptides obtained from Diplulmaris antarctica, a jellyfish of the Antarctic region
title Anti-obesity effect of collagen peptides obtained from Diplulmaris antarctica, a jellyfish of the Antarctic region
title_full Anti-obesity effect of collagen peptides obtained from Diplulmaris antarctica, a jellyfish of the Antarctic region
title_fullStr Anti-obesity effect of collagen peptides obtained from Diplulmaris antarctica, a jellyfish of the Antarctic region
title_full_unstemmed Anti-obesity effect of collagen peptides obtained from Diplulmaris antarctica, a jellyfish of the Antarctic region
title_short Anti-obesity effect of collagen peptides obtained from Diplulmaris antarctica, a jellyfish of the Antarctic region
title_sort anti-obesity effect of collagen peptides obtained from diplulmaris antarctica, a jellyfish of the antarctic region
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10028559/
https://www.ncbi.nlm.nih.gov/pubmed/36864815
http://dx.doi.org/10.3325/cmj.2023.64.21
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