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Phase 1 pilot study of RRx-001 + nivolumab in patients with advanced metastatic cancer (PRIMETIME)

BACKGROUND: Bromonitrozidine (RRx-001) is a minimally toxic, NLRP3 inhibitor that has been observed, in experimental systems, to also downregulate CD47, repolarize tumor associated macrophages (TAMs) and normalize aberrant tumor perfusion. This phase 1 pilot study was undertaken to determine the saf...

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Detalles Bibliográficos
Autores principales:	Reid, Tony, Oronsky, Bryan, Caroen, Scott, Quinn, Mary, Williams, Jeannie, Cabrales, Pedro, Abrouk, Nacer
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10028591/ https://www.ncbi.nlm.nih.gov/pubmed/36960054 http://dx.doi.org/10.3389/fimmu.2023.1104753

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