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Amygdala‐frontoparietal effective connectivity in creativity and humor processing

Although both creativity and humor elicit experiences of surprise followed by appreciation, it remains unknown whether shared or distinct patterns of effective connectivity are involved in their processing. The present fMRI study used dynamic causal modeling and parametrical empirical Bayes analysis...

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Autores principales: Chan, Yu‐Chen, Zeitlen, Daniel C., Beaty, Roger E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10028645/
https://www.ncbi.nlm.nih.gov/pubmed/36773031
http://dx.doi.org/10.1002/hbm.26232
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author Chan, Yu‐Chen
Zeitlen, Daniel C.
Beaty, Roger E.
author_facet Chan, Yu‐Chen
Zeitlen, Daniel C.
Beaty, Roger E.
author_sort Chan, Yu‐Chen
collection PubMed
description Although both creativity and humor elicit experiences of surprise followed by appreciation, it remains unknown whether shared or distinct patterns of effective connectivity are involved in their processing. The present fMRI study used dynamic causal modeling and parametrical empirical Bayes analysis to examine the effective connectivity between the amygdala and frontoparietal network during two‐stage creativity and humor processing. We examined processing during the setup and punch line stages for creativity and humor, including typical forms (alternate uses for creativity and incongruity‐resolution humor), atypical forms (aesthetic uses for creativity and nonsense humor), and baseline forms. Our focus was on the mesolimbic pathway during the punch line stage. We found that the amygdala plays a key role in expectation violation and appreciation. Broadly, amygdala‐to‐IFG connectivity was important for evaluating typical and atypical forms of both creativity and humor, while amygdala‐to‐precuneus connectivity was involved in evaluating typical forms. Amygdala‐to‐IFG connectivity was involved in the expectation violation to resolution stage of processing for typical and atypical forms of creativity and humor. Amygdala‐to‐precuneus connectivity was involved in processing the novelty and usefulness of typical forms of creativity (alternate uses) and understanding others' intentions in typical forms of humor (incongruity‐resolution). Interestingly, VTA‐to‐amygdala connectivity was involved in processing the appreciation of both typical (incongruity‐resolution humor) and atypical (nonsense humor) forms of humor while amygdala‐to‐VTA connectivity was involved in processing the appreciation of atypical (aesthetic uses) forms of creativity. Altogether, these findings suggest that the amygdala and frontoparietal circuitry are critical for creativity and humor processing.
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spelling pubmed-100286452023-03-22 Amygdala‐frontoparietal effective connectivity in creativity and humor processing Chan, Yu‐Chen Zeitlen, Daniel C. Beaty, Roger E. Hum Brain Mapp Research Articles Although both creativity and humor elicit experiences of surprise followed by appreciation, it remains unknown whether shared or distinct patterns of effective connectivity are involved in their processing. The present fMRI study used dynamic causal modeling and parametrical empirical Bayes analysis to examine the effective connectivity between the amygdala and frontoparietal network during two‐stage creativity and humor processing. We examined processing during the setup and punch line stages for creativity and humor, including typical forms (alternate uses for creativity and incongruity‐resolution humor), atypical forms (aesthetic uses for creativity and nonsense humor), and baseline forms. Our focus was on the mesolimbic pathway during the punch line stage. We found that the amygdala plays a key role in expectation violation and appreciation. Broadly, amygdala‐to‐IFG connectivity was important for evaluating typical and atypical forms of both creativity and humor, while amygdala‐to‐precuneus connectivity was involved in evaluating typical forms. Amygdala‐to‐IFG connectivity was involved in the expectation violation to resolution stage of processing for typical and atypical forms of creativity and humor. Amygdala‐to‐precuneus connectivity was involved in processing the novelty and usefulness of typical forms of creativity (alternate uses) and understanding others' intentions in typical forms of humor (incongruity‐resolution). Interestingly, VTA‐to‐amygdala connectivity was involved in processing the appreciation of both typical (incongruity‐resolution humor) and atypical (nonsense humor) forms of humor while amygdala‐to‐VTA connectivity was involved in processing the appreciation of atypical (aesthetic uses) forms of creativity. Altogether, these findings suggest that the amygdala and frontoparietal circuitry are critical for creativity and humor processing. John Wiley & Sons, Inc. 2023-02-11 /pmc/articles/PMC10028645/ /pubmed/36773031 http://dx.doi.org/10.1002/hbm.26232 Text en © 2023 The Authors. Human Brain Mapping published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Research Articles
Chan, Yu‐Chen
Zeitlen, Daniel C.
Beaty, Roger E.
Amygdala‐frontoparietal effective connectivity in creativity and humor processing
title Amygdala‐frontoparietal effective connectivity in creativity and humor processing
title_full Amygdala‐frontoparietal effective connectivity in creativity and humor processing
title_fullStr Amygdala‐frontoparietal effective connectivity in creativity and humor processing
title_full_unstemmed Amygdala‐frontoparietal effective connectivity in creativity and humor processing
title_short Amygdala‐frontoparietal effective connectivity in creativity and humor processing
title_sort amygdala‐frontoparietal effective connectivity in creativity and humor processing
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10028645/
https://www.ncbi.nlm.nih.gov/pubmed/36773031
http://dx.doi.org/10.1002/hbm.26232
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