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Brain deficit patterns of metabolic illnesses overlap with those for major depressive disorder: A new metric of brain metabolic disease

Metabolic illnesses (MET) are detrimental to brain integrity and are common comorbidities in patients with mental illnesses, including major depressive disorder (MDD). We quantified effects of MET on standard regional brain morphometric measures from 3D brain MRI as well as diffusion MRI in a large...

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Autores principales: Hatch, Kathryn S., Gao, Si, Ma, Yizhou, Russo, Alessandro, Jahanshad, Neda, Thompson, Paul M., Adhikari, Bhim M., Bruce, Heather, Van der Vaart, Andrew, Sotiras, Aristeidis, Kvarta, Mark D., Nichols, Thomas E., Schmaal, Lianne, Hong, L. Elliot, Kochunov, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10028678/
https://www.ncbi.nlm.nih.gov/pubmed/36799565
http://dx.doi.org/10.1002/hbm.26235
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author Hatch, Kathryn S.
Gao, Si
Ma, Yizhou
Russo, Alessandro
Jahanshad, Neda
Thompson, Paul M.
Adhikari, Bhim M.
Bruce, Heather
Van der Vaart, Andrew
Sotiras, Aristeidis
Kvarta, Mark D.
Nichols, Thomas E.
Schmaal, Lianne
Hong, L. Elliot
Kochunov, Peter
author_facet Hatch, Kathryn S.
Gao, Si
Ma, Yizhou
Russo, Alessandro
Jahanshad, Neda
Thompson, Paul M.
Adhikari, Bhim M.
Bruce, Heather
Van der Vaart, Andrew
Sotiras, Aristeidis
Kvarta, Mark D.
Nichols, Thomas E.
Schmaal, Lianne
Hong, L. Elliot
Kochunov, Peter
author_sort Hatch, Kathryn S.
collection PubMed
description Metabolic illnesses (MET) are detrimental to brain integrity and are common comorbidities in patients with mental illnesses, including major depressive disorder (MDD). We quantified effects of MET on standard regional brain morphometric measures from 3D brain MRI as well as diffusion MRI in a large sample of UK BioBank participants. The pattern of regional effect sizes of MET in non‐psychiatric UKBB subjects was significantly correlated with the spatial profile of regional effects reported by the largest meta‐analyses in MDD but not in bipolar disorder, schizophrenia or Alzheimer's disease. We used a regional vulnerability index (RVI) for MET (RVI‐MET) to measure individual's brain similarity to the expected patterns in MET in the UK Biobank sample. Subjects with MET showed a higher effect size for RVI‐MET than for any of the individual brain measures. We replicated elevation of RVI‐MET in a sample of MDD participants with MET versus non‐MET. RVI‐MET scores were significantly correlated with the volume of white matter hyperintensities, a neurological consequence of MET and age, in both groups. Higher RVI‐MET in both samples was associated with obesity, tobacco smoking and frequent alcohol use but was unrelated to antidepressant use. In summary, MET effects on the brain were regionally specific and individual similarity to the pattern was more strongly associated with MET than any regional brain structural metric. Effects of MET overlapped with the reported brain differences in MDD, likely due to higher incidence of MET, smoking and alcohol use in subjects with MDD.
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spelling pubmed-100286782023-03-22 Brain deficit patterns of metabolic illnesses overlap with those for major depressive disorder: A new metric of brain metabolic disease Hatch, Kathryn S. Gao, Si Ma, Yizhou Russo, Alessandro Jahanshad, Neda Thompson, Paul M. Adhikari, Bhim M. Bruce, Heather Van der Vaart, Andrew Sotiras, Aristeidis Kvarta, Mark D. Nichols, Thomas E. Schmaal, Lianne Hong, L. Elliot Kochunov, Peter Hum Brain Mapp Research Articles Metabolic illnesses (MET) are detrimental to brain integrity and are common comorbidities in patients with mental illnesses, including major depressive disorder (MDD). We quantified effects of MET on standard regional brain morphometric measures from 3D brain MRI as well as diffusion MRI in a large sample of UK BioBank participants. The pattern of regional effect sizes of MET in non‐psychiatric UKBB subjects was significantly correlated with the spatial profile of regional effects reported by the largest meta‐analyses in MDD but not in bipolar disorder, schizophrenia or Alzheimer's disease. We used a regional vulnerability index (RVI) for MET (RVI‐MET) to measure individual's brain similarity to the expected patterns in MET in the UK Biobank sample. Subjects with MET showed a higher effect size for RVI‐MET than for any of the individual brain measures. We replicated elevation of RVI‐MET in a sample of MDD participants with MET versus non‐MET. RVI‐MET scores were significantly correlated with the volume of white matter hyperintensities, a neurological consequence of MET and age, in both groups. Higher RVI‐MET in both samples was associated with obesity, tobacco smoking and frequent alcohol use but was unrelated to antidepressant use. In summary, MET effects on the brain were regionally specific and individual similarity to the pattern was more strongly associated with MET than any regional brain structural metric. Effects of MET overlapped with the reported brain differences in MDD, likely due to higher incidence of MET, smoking and alcohol use in subjects with MDD. John Wiley & Sons, Inc. 2023-02-17 /pmc/articles/PMC10028678/ /pubmed/36799565 http://dx.doi.org/10.1002/hbm.26235 Text en © 2023 The Authors. Human Brain Mapping published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Research Articles
Hatch, Kathryn S.
Gao, Si
Ma, Yizhou
Russo, Alessandro
Jahanshad, Neda
Thompson, Paul M.
Adhikari, Bhim M.
Bruce, Heather
Van der Vaart, Andrew
Sotiras, Aristeidis
Kvarta, Mark D.
Nichols, Thomas E.
Schmaal, Lianne
Hong, L. Elliot
Kochunov, Peter
Brain deficit patterns of metabolic illnesses overlap with those for major depressive disorder: A new metric of brain metabolic disease
title Brain deficit patterns of metabolic illnesses overlap with those for major depressive disorder: A new metric of brain metabolic disease
title_full Brain deficit patterns of metabolic illnesses overlap with those for major depressive disorder: A new metric of brain metabolic disease
title_fullStr Brain deficit patterns of metabolic illnesses overlap with those for major depressive disorder: A new metric of brain metabolic disease
title_full_unstemmed Brain deficit patterns of metabolic illnesses overlap with those for major depressive disorder: A new metric of brain metabolic disease
title_short Brain deficit patterns of metabolic illnesses overlap with those for major depressive disorder: A new metric of brain metabolic disease
title_sort brain deficit patterns of metabolic illnesses overlap with those for major depressive disorder: a new metric of brain metabolic disease
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10028678/
https://www.ncbi.nlm.nih.gov/pubmed/36799565
http://dx.doi.org/10.1002/hbm.26235
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