A Biological OR(XNOR) Logic Gate Couples Carbon Source and Transgene Expression Switching in a Komagataella phaffii (Pichia pastoris) Strain Co-producing Process-Enhancing Lipase and a Virus-like Particle (VLP) Vaccine

[Image: see text] We constructed a three-input biological logic gate: S OR (G XNOR M), where S is sorbitol, G is glycerol, and M is methanol, to optimize co-expression of two transgenes in Komagataella phaffii using batch-mode carbon source switching (CSS). K. phaffii was engineered to harbor transg...

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Detalles Bibliográficos
Autores principales: Bandyopadhyay, Sushobhan, Pavlika, Vasos, Bracewell, Daniel G., Nesbeth, Darren N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10028693/
https://www.ncbi.nlm.nih.gov/pubmed/36848292
http://dx.doi.org/10.1021/acssynbio.2c00342

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