Cargando…
Structure-Kinetics Relationships of Opioids from Metadynamics and Machine Learning
The nation’s opioid overdose deaths reached an all-time high in 2021. The majority of deaths are due to synthetic opioids represented by fentanyl. Naloxone, which is a FDA-approved reversal agent, antagonizes opioids through competitive binding at the μ-opioid receptor (mOR). Thus, knowledge of opio...
| Autores principales: | , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cold Spring Harbor Laboratory
2023
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10028827/ https://www.ncbi.nlm.nih.gov/pubmed/36945599 http://dx.doi.org/10.1101/2023.03.06.531338 |