Glioblastoma-instructed microglia transit to heterogeneous phenotypic states with phagocytic and dendritic cell-like features in patient tumors and patient-derived orthotopic xenografts

BACKGROUND: Glioblastoma (GBM) evades the immune system by creating an immune-suppressive tumor microenvironment (TME), where GBM-associated myeloid cells are geared towards tumor-supportive roles. However, it is unclear whether recruited myeloid cells are phenotypically and functionally identical....

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Detalles Bibliográficos
Autores principales: Yabo, Yahaya A., Moreno-Sanchez, Pilar M., Pires-Afonso, Yolanda, Kaoma, Tony, Kyriakis, Dimitrios, Grzyb, Kamil, Poovathingal, Suresh K., Poli, Aurélie, Scafidi, Andrea, Muller, Arnaud, Toth, Reka, Oudin, Anaïs, Klink, Barbara, Berchem, Guy, Berthold, Christophe, Hertel, Frank, Mittelbronn, Michel, Heiland, Dieter H., Skupin, Alexander, Nazarov, Petr V., Niclou, Simone P., Michelucci, Alessandro, Golebiewska, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10028830/
https://www.ncbi.nlm.nih.gov/pubmed/36945572
http://dx.doi.org/10.1101/2023.03.05.531162

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