O-GlcNAc modification forces the formation of an α-Synuclein amyloid-strain with notably diminished seeding activity and pathology

The process of amyloid fibril formation remains one of the primary targets for developing diagnostics and treatments for several neurodegenerative diseases (NDDs). Amyloid-forming proteins such α-Synuclein and Tau, which are implicated in the pathogenesis of Alzheimer’s and Parkinson’s disease, can...

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Detalles Bibliográficos
Autores principales: Balana, Aaron T., Mahul-Mellier, Anne-Laure, Nguyen, Binh A, Horvath, Mian, Javed, Afraah, Hard, Eldon R., Jasiqi, Yllza, Singh, Preeti, Afrin, Shumaila, Pedretti, Rose, Singh, Virender, Lee, Virginia M.-Y., Luk, Kelvin C., Saelices, Lorena, Lashuel, Hilal A., Pratt, Matthew R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10028859/
https://www.ncbi.nlm.nih.gov/pubmed/36945566
http://dx.doi.org/10.1101/2023.03.07.531573

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