Single Nucleus Transcriptomics Reveals Pervasive Glial Activation in Opioid Overdose Cases

Dynamic interactions of neurons and glia in the ventral midbrain (VM) mediate reward and addiction behavior. We studied gene expression in 212,713 VM single nuclei from 95 human opioid overdose cases and drug-free controls. Chronic exposure to opioids left numerical proportions of VM glial and neuro...

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Detalles Bibliográficos
Autores principales: Wei, Julong, Lambert, Tova Y., Valada, Aditi, Patel, Nikhil, Walker, Kellie, Lenders, Jayna, Schmidt, Carl J., Iskhakova, Marina, Alazizi, Adnan, Mair-Meijers, Henriette, Mash, Deborah C., Luca, Francesca, Pique-Regi, Roger, Bannon, Michael J, Akbarian, Schahram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10028861/
https://www.ncbi.nlm.nih.gov/pubmed/36945611
http://dx.doi.org/10.1101/2023.03.07.531400

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