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Naturally-acquired and Vaccine-induced Human Monoclonal Antibodies to Plasmodium vivax Duffy Binding Protein Inhibit Invasion of Plasmodium knowlesi (PvDBPOR) Transgenic Parasites

The Duffy antigen receptor for chemokines (DARC) expressed on erythrocytes is central to Plasmodium vivax (Pv) invasion of reticulocytes. Pv expresses a Duffy binding protein (PvDBP) on merozoites, a DARC ligand, and their protein-protein interaction is central to vivax blood stage malaria. Here we...

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Detalles Bibliográficos
Autores principales: Watson, Quentin D., Carias, Lenore L., Malachin, Alyssa, Redinger, Karli R., Bosch, Jürgen, Bardelli, Martino, Moon, Robert W., Draper, Simon J., Zimmerman, Peter A., King, Christopher L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10028882/
https://www.ncbi.nlm.nih.gov/pubmed/36945444
http://dx.doi.org/10.1101/2023.03.07.531647