Aberrant phase separation is a common killing strategy of positively charged peptides in biology and human disease

Positively charged repeat peptides are emerging as key players in neurodegenerative diseases. These peptides can perturb diverse cellular pathways but a unifying framework for how such promiscuous toxicity arises has remained elusive. We used mass-spectrometry-based proteomics to define the protein...

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Detalles Bibliográficos
Autores principales: Boeynaems, Steven, Ma, X. Rosa, Yeong, Vivian, Ginell, Garrett M., Chen, Jian-Hua, Blum, Jacob A., Nakayama, Lisa, Sanyal, Anushka, Briner, Adam, Haver, Delphi Van, Pauwels, Jarne, Ekman, Axel, Schmidt, H. Broder, Sundararajan, Kousik, Porta, Lucas, Lasker, Keren, Larabell, Carolyn, Hayashi, Mirian A. F., Kundaje, Anshul, Impens, Francis, Obermeyer, Allie, Holehouse, Alex S., Gitler, Aaron D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10028949/
https://www.ncbi.nlm.nih.gov/pubmed/36945394
http://dx.doi.org/10.1101/2023.03.09.531820

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