A molecular glue approach to control the half-life of CRISPR-based technologies

Cas9 is a programmable nuclease that has furnished transformative technologies, including base editors and transcription modulators (e.g., CRISPRi/a), but several applications of these technologies, including therapeutics, mandatorily require precision control of their half-life. For example, such c...

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Detalles Bibliográficos
Autores principales: Sreekanth, Vedagopuram, Jan, Max, Zhao, Kevin T., Lim, Donghyun, Davis, Jessie R., McConkey, Marie, Kovalcik, Veronica, Barkal, Sam, Law, Benjamin K., Fife, James, Tian, Ruilin, Vinyard, Michael E., Becerra, Basheer, Kampmann, Martin, Sherwood, Richard I., Pinello, Luca, Liu, David R., Ebert, Benjamin L., Choudhary, Amit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10028966/
https://www.ncbi.nlm.nih.gov/pubmed/36945568
http://dx.doi.org/10.1101/2023.03.12.531757

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