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Structure-Activity Relationships, Tolerability and Efficacy of Microtubule-Active 1,2,4-Triazolo[1,5-a]pyrimidines as Potential Candidates to Treat Human African Trypanosomiasis

Tubulin and microtubules (MTs) are potential protein targets to treat parasitic infections and our previous studies have shown that the triazolopyrimidine (TPD) class of MT-active compounds hold promise as antitrypanosomal agents. MT-targeting TPDs include structurally related but functionally diver...

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Detalles Bibliográficos
Autores principales:	Monti, Ludovica, Liu, Lawrence J., Varricchio, Carmine, Lucero, Bobby, Alle, Thibault, Yang, Wenqian, Bem-Shalom, Ido, Gilson, Michael, Brunden, Kurt R., Brancale, Andrea, Caffrey, Conor R., Ballatore, Carlo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10028969/ https://www.ncbi.nlm.nih.gov/pubmed/36945407 http://dx.doi.org/10.1101/2023.03.11.532093

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