Ophiobolin A Covalently Targets Complex IV Leading to Mitochondrial Metabolic Collapse in Cancer Cells

Ophiobolin A (OPA) is a sesterterpenoid fungal natural product with broad anti-cancer activity. While OPA possesses multiple electrophilic moieties that can covalently react with nucleophilic amino acids on proteins, the proteome-wide targets and mechanism of OPA remain poorly understood in many con...

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Detalles Bibliográficos
Autores principales: Gowans, Flor A., Thach, Danny Q., Wang, Yangzhi, Altamirano Poblano, Belen E., Dovala, Dustin, Tallarico, John A., McKenna, Jeffrey M., Schirle, Markus, Maimone, Thomas J., Nomura, Daniel K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10029012/
https://www.ncbi.nlm.nih.gov/pubmed/36945520
http://dx.doi.org/10.1101/2023.03.09.531918

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