PAM-Flexible Genome Editing with an Engineered Chimeric Cas9

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CRISPR enzymes require a defined protospacer adjacent motif (PAM) flanking a guide RNA-programmed target site, limiting their sequence accessibility for robust genome editing applications. In this study, we recombine the PAM-interacting domain of SpRY, a broad-targeting Cas9 possessing an NRN > N...

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Detalles Bibliográficos
Autores principales: Koseki, Sabrina, Hong, Lauren, Yudistyra, Vivian, Stan, Teodora, Tysinger, Emma, Silverstein, Rachel, Kramme, Christian, Amrani, Nadia, Savic, Natasha, Pacesa, Martin, Rodriguez, Tomás, Ponnapati, Manvitha, Jacobson, Joseph, Church, George, Truant, Ray, Jinek, Martin, Kleinstiver, Benjamin, Sontheimer, Erik, Chatterjee, Pranam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10029082/
https://www.ncbi.nlm.nih.gov/pubmed/36945419
http://dx.doi.org/10.21203/rs.3.rs-2625838/v1
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