Novel Scheme for Defining the Clinical Implications of TP53 Mutations in Myeloid Neoplasia

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BACKGROUND: TP53 mutations (TP53(MT)) occur in diverse genomic configurations. Particularly, biallelic inactivation is associated with poor overall survival in cancer. Lesions affecting only one allele might not be directly leukemogenic, questioning the presence of cryptic biallelic subclones in cas...

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Detalles Bibliográficos
Autores principales: Bahaj, Waled, Kewan, Tariq, Gurnari, Carmelo, Durmaz, Arda, Ponvilawan, Ben, Pandit, Ishani, Kubota, Yasuo, Ogbue, Olisaemeka D., Zawit, Misam, Madanat, Yazan, Bat, Taha, Balasubramanian, Suresh K., Awada, Hussein, Ahmed, Ramsha, Mori, Minako, Meggendorfer, Manja, Haferlach, Torsten, Visconte, Valeria, Maciejewski, Jaroslaw P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10029089/
https://www.ncbi.nlm.nih.gov/pubmed/36945617
http://dx.doi.org/10.21203/rs.3.rs-2656206/v1
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