Mesoporous nanodrug delivery system: a powerful tool for a new paradigm of remodeling of the tumor microenvironment

Tumor microenvironment (TME) plays an important role in tumor progression, metastasis and therapy resistance. Remodeling the TME has recently been deemed an attractive tumor therapeutic strategy. Due to its complexity and heterogeneity, remodeling the TME still faces great challenges. With the great...

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Autores principales: Hang, Yinhui, Liu, Yanfang, Teng, Zhaogang, Cao, Xiongfeng, Zhu, Haitao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10029196/
https://www.ncbi.nlm.nih.gov/pubmed/36945005
http://dx.doi.org/10.1186/s12951-023-01841-2
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author Hang, Yinhui
Liu, Yanfang
Teng, Zhaogang
Cao, Xiongfeng
Zhu, Haitao
author_facet Hang, Yinhui
Liu, Yanfang
Teng, Zhaogang
Cao, Xiongfeng
Zhu, Haitao
author_sort Hang, Yinhui
collection PubMed
description Tumor microenvironment (TME) plays an important role in tumor progression, metastasis and therapy resistance. Remodeling the TME has recently been deemed an attractive tumor therapeutic strategy. Due to its complexity and heterogeneity, remodeling the TME still faces great challenges. With the great advantage of drug loading ability, tumor accumulation, multifactor controllability, and persistent guest molecule release ability, mesoporous nanodrug delivery systems (MNDDSs) have been widely used as effective antitumor drug delivery tools as well as remolding TME. This review summarizes the components and characteristics of the TME, as well as the crosstalk between the TME and cancer cells and focuses on the important role of drug delivery strategies based on MNDDSs in targeted remodeling TME metabolic and synergistic anticancer therapy. GRAPHICAL ABSTRACT: [Image: see text]
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spelling pubmed-100291962023-03-22 Mesoporous nanodrug delivery system: a powerful tool for a new paradigm of remodeling of the tumor microenvironment Hang, Yinhui Liu, Yanfang Teng, Zhaogang Cao, Xiongfeng Zhu, Haitao J Nanobiotechnology Review Tumor microenvironment (TME) plays an important role in tumor progression, metastasis and therapy resistance. Remodeling the TME has recently been deemed an attractive tumor therapeutic strategy. Due to its complexity and heterogeneity, remodeling the TME still faces great challenges. With the great advantage of drug loading ability, tumor accumulation, multifactor controllability, and persistent guest molecule release ability, mesoporous nanodrug delivery systems (MNDDSs) have been widely used as effective antitumor drug delivery tools as well as remolding TME. This review summarizes the components and characteristics of the TME, as well as the crosstalk between the TME and cancer cells and focuses on the important role of drug delivery strategies based on MNDDSs in targeted remodeling TME metabolic and synergistic anticancer therapy. GRAPHICAL ABSTRACT: [Image: see text] BioMed Central 2023-03-21 /pmc/articles/PMC10029196/ /pubmed/36945005 http://dx.doi.org/10.1186/s12951-023-01841-2 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Hang, Yinhui
Liu, Yanfang
Teng, Zhaogang
Cao, Xiongfeng
Zhu, Haitao
Mesoporous nanodrug delivery system: a powerful tool for a new paradigm of remodeling of the tumor microenvironment
title Mesoporous nanodrug delivery system: a powerful tool for a new paradigm of remodeling of the tumor microenvironment
title_full Mesoporous nanodrug delivery system: a powerful tool for a new paradigm of remodeling of the tumor microenvironment
title_fullStr Mesoporous nanodrug delivery system: a powerful tool for a new paradigm of remodeling of the tumor microenvironment
title_full_unstemmed Mesoporous nanodrug delivery system: a powerful tool for a new paradigm of remodeling of the tumor microenvironment
title_short Mesoporous nanodrug delivery system: a powerful tool for a new paradigm of remodeling of the tumor microenvironment
title_sort mesoporous nanodrug delivery system: a powerful tool for a new paradigm of remodeling of the tumor microenvironment
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10029196/
https://www.ncbi.nlm.nih.gov/pubmed/36945005
http://dx.doi.org/10.1186/s12951-023-01841-2
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