TAK-715 alleviated IL-1β-induced apoptosis and ECM degradation in nucleus pulposus cells and attenuated intervertebral disc degeneration ex vivo and in vivo

BACKGROUND: Intervertebral disc degeneration (IDD) is one of the most common disorders related to the spine. Inflammation, apoptosis and extracellular matrix (ECM) degradation contribute to disc degeneration in nucleus pulposus cells (NPCs). This study focused on the role and mechanism of the p38 in...

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Detalles Bibliográficos
Autores principales: Wang, Kun, Yao, Dengbo, Li, Yuxi, Li, Ming, Zeng, Weike, Liao, Zhuangyao, Chen, Engming, Lu, Shixin, Su, Kaihui, Che, Zhen, Liang, Yuwei, Wang, Peng, Huang, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10029231/
https://www.ncbi.nlm.nih.gov/pubmed/36945021
http://dx.doi.org/10.1186/s13075-023-03028-4

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