BM-MSCs overexpressing the Numb enhance the therapeutic effect on cholestatic liver fibrosis by inhibiting the ductular reaction

BACKGROUND: Cholestatic liver fibrosis (CLF) is caused by inflammatory destruction of the intrahepatic bile duct and abnormal proliferation of the small bile duct after cholestasis. Activation of the Notch signaling pathway is required for hepatic stem cells to differentiate into cholangiocytes duri...

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Detalles Bibliográficos
Autores principales: Xu, Yan-nan, Xu, Wen, Zhang, Xu, Wang, Dan-yang, Zheng, Xin-rui, Liu, Wei, Chen, Jia-mei, Chen, Gao-feng, Liu, Cheng-hai, Liu, Ping, Mu, Yong-ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10029310/
https://www.ncbi.nlm.nih.gov/pubmed/36941658
http://dx.doi.org/10.1186/s13287-023-03276-w

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