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Clinical characteristics and outcomes of Mott cell lymphoma in nine miniature dachshunds

BACKGROUND: Lymphoma with Mott cell change, or Mott cell lymphoma (MCL), is an uncommon variant of canine lymphoma. Because of its rare occurrence, there has been no comprehensive study describing the disease so far. Miniature dachshunds, a popular breed in Japan, sometimes experience MCL. OBJECTIVE...

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Autores principales: Ohmi, Aki, Tanaka, Miho, Rinno, Jun, Tsuboi, Masaya, Chambers, James K., Uchida, Kazuyuki, Goto‐Koshino, Yuko, Tomiyasu, Hirotaka, Ohno, Koichi, Tsujimoto, Hajime
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10029887/
https://www.ncbi.nlm.nih.gov/pubmed/36401603
http://dx.doi.org/10.1002/vms3.975
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author Ohmi, Aki
Tanaka, Miho
Rinno, Jun
Tsuboi, Masaya
Chambers, James K.
Uchida, Kazuyuki
Goto‐Koshino, Yuko
Tomiyasu, Hirotaka
Ohno, Koichi
Tsujimoto, Hajime
author_facet Ohmi, Aki
Tanaka, Miho
Rinno, Jun
Tsuboi, Masaya
Chambers, James K.
Uchida, Kazuyuki
Goto‐Koshino, Yuko
Tomiyasu, Hirotaka
Ohno, Koichi
Tsujimoto, Hajime
author_sort Ohmi, Aki
collection PubMed
description BACKGROUND: Lymphoma with Mott cell change, or Mott cell lymphoma (MCL), is an uncommon variant of canine lymphoma. Because of its rare occurrence, there has been no comprehensive study describing the disease so far. Miniature dachshunds, a popular breed in Japan, sometimes experience MCL. OBJECTIVES: To investigate the clinical characteristics and outcomes of MCL in miniature dachshunds. METHODS: Medical records were retrospectively reviewed to identify miniature dachshunds diagnosed with MCL and other types of lymphoma. Data on clinical and laboratory findings, treatments and outcomes were collected. Survival times were compared between miniature dachshunds with MCL and other types of lymphoma. RESULTS: Of the 87 miniature dachshunds diagnosed with lymphoma, 9 (10%) had cytological characteristics of MCL. All 9 miniature dachshunds with MCL were categorised as having alimentary lymphoma (small and/or large intestine, 6 dogs; mesenteric lymph node, 3 dogs). The median age was 3.1 years (range, 2.0–9.4 years). All nine dogs were treated with chemotherapeutic protocols used for large cell lymphoma or alkylating agents such as melphalan or chlorambucil. The overall response rate to initial chemotherapy was 78%, and the median progression‐free survival was 105 days. Overall survival in these nine dogs ranged from 6 to >1513 days (median, 240 days), which was significantly longer than in 29 miniature dachshunds with alimentary large cell lymphoma other than MCL (median, 57 days; p = 0.0491). CONCLUSIONS: MCL in miniature dachshunds can be recognised as a peculiar type of B‐cell lymphoma occurring in relatively young dogs as an alimentary form and has a longer survival compared with typical alimentary large cell lymphoma.
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spelling pubmed-100298872023-03-22 Clinical characteristics and outcomes of Mott cell lymphoma in nine miniature dachshunds Ohmi, Aki Tanaka, Miho Rinno, Jun Tsuboi, Masaya Chambers, James K. Uchida, Kazuyuki Goto‐Koshino, Yuko Tomiyasu, Hirotaka Ohno, Koichi Tsujimoto, Hajime Vet Med Sci DOGS BACKGROUND: Lymphoma with Mott cell change, or Mott cell lymphoma (MCL), is an uncommon variant of canine lymphoma. Because of its rare occurrence, there has been no comprehensive study describing the disease so far. Miniature dachshunds, a popular breed in Japan, sometimes experience MCL. OBJECTIVES: To investigate the clinical characteristics and outcomes of MCL in miniature dachshunds. METHODS: Medical records were retrospectively reviewed to identify miniature dachshunds diagnosed with MCL and other types of lymphoma. Data on clinical and laboratory findings, treatments and outcomes were collected. Survival times were compared between miniature dachshunds with MCL and other types of lymphoma. RESULTS: Of the 87 miniature dachshunds diagnosed with lymphoma, 9 (10%) had cytological characteristics of MCL. All 9 miniature dachshunds with MCL were categorised as having alimentary lymphoma (small and/or large intestine, 6 dogs; mesenteric lymph node, 3 dogs). The median age was 3.1 years (range, 2.0–9.4 years). All nine dogs were treated with chemotherapeutic protocols used for large cell lymphoma or alkylating agents such as melphalan or chlorambucil. The overall response rate to initial chemotherapy was 78%, and the median progression‐free survival was 105 days. Overall survival in these nine dogs ranged from 6 to >1513 days (median, 240 days), which was significantly longer than in 29 miniature dachshunds with alimentary large cell lymphoma other than MCL (median, 57 days; p = 0.0491). CONCLUSIONS: MCL in miniature dachshunds can be recognised as a peculiar type of B‐cell lymphoma occurring in relatively young dogs as an alimentary form and has a longer survival compared with typical alimentary large cell lymphoma. John Wiley and Sons Inc. 2022-11-19 /pmc/articles/PMC10029887/ /pubmed/36401603 http://dx.doi.org/10.1002/vms3.975 Text en © 2022 The Authors. Veterinary Medicine and Science published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle DOGS
Ohmi, Aki
Tanaka, Miho
Rinno, Jun
Tsuboi, Masaya
Chambers, James K.
Uchida, Kazuyuki
Goto‐Koshino, Yuko
Tomiyasu, Hirotaka
Ohno, Koichi
Tsujimoto, Hajime
Clinical characteristics and outcomes of Mott cell lymphoma in nine miniature dachshunds
title Clinical characteristics and outcomes of Mott cell lymphoma in nine miniature dachshunds
title_full Clinical characteristics and outcomes of Mott cell lymphoma in nine miniature dachshunds
title_fullStr Clinical characteristics and outcomes of Mott cell lymphoma in nine miniature dachshunds
title_full_unstemmed Clinical characteristics and outcomes of Mott cell lymphoma in nine miniature dachshunds
title_short Clinical characteristics and outcomes of Mott cell lymphoma in nine miniature dachshunds
title_sort clinical characteristics and outcomes of mott cell lymphoma in nine miniature dachshunds
topic DOGS
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10029887/
https://www.ncbi.nlm.nih.gov/pubmed/36401603
http://dx.doi.org/10.1002/vms3.975
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