Real-Time Whole Genome Sequencing to Guide Patient-Tailored Therapy of Severe Acute Respiratory Syndrome Coronavirus 2 Infection

The management of coronavirus disease 2019 has become more complex due to the expansion of available therapies. The presence of severe acute respiratory syndrome coronavirus 2 variants and mutations further complicates treatment due to their differing susceptibilities to therapies. Here we outline t...

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Detalles Bibliográficos
Autores principales: Snell, Luke B, Alcolea-Medina, Adela, Charalampous, Themoula, Alder, Christopher, Williams, Tom G S, Flaviani, Flavia, Batra, Rahul, Bakrania, Prijay, Thangarajah, Rajeni, Neil, Stuart J D, van Nispen tot Pannerden, Claire, Botgros, Alina, Aarons, Emma, Douthwaite, Samuel T, Edgeworth, Jonathan D, Nebbia, Gaia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10029986/
https://www.ncbi.nlm.nih.gov/pubmed/36327795
http://dx.doi.org/10.1093/cid/ciac864
Descripción
Sumario:The management of coronavirus disease 2019 has become more complex due to the expansion of available therapies. The presence of severe acute respiratory syndrome coronavirus 2 variants and mutations further complicates treatment due to their differing susceptibilities to therapies. Here we outline the use of real-time whole genome sequencing to detect persistent infection, evaluate for mutations confering resistance to treatments, and guide treatment decisions.

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