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Real-Time Whole Genome Sequencing to Guide Patient-Tailored Therapy of Severe Acute Respiratory Syndrome Coronavirus 2 Infection
The management of coronavirus disease 2019 has become more complex due to the expansion of available therapies. The presence of severe acute respiratory syndrome coronavirus 2 variants and mutations further complicates treatment due to their differing susceptibilities to therapies. Here we outline t...
| Autores principales: | , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10029986/ https://www.ncbi.nlm.nih.gov/pubmed/36327795 http://dx.doi.org/10.1093/cid/ciac864 |
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| author | Snell, Luke B Alcolea-Medina, Adela Charalampous, Themoula Alder, Christopher Williams, Tom G S Flaviani, Flavia Batra, Rahul Bakrania, Prijay Thangarajah, Rajeni Neil, Stuart J D van Nispen tot Pannerden, Claire Botgros, Alina Aarons, Emma Douthwaite, Samuel T Edgeworth, Jonathan D Nebbia, Gaia |
| author_facet | Snell, Luke B Alcolea-Medina, Adela Charalampous, Themoula Alder, Christopher Williams, Tom G S Flaviani, Flavia Batra, Rahul Bakrania, Prijay Thangarajah, Rajeni Neil, Stuart J D van Nispen tot Pannerden, Claire Botgros, Alina Aarons, Emma Douthwaite, Samuel T Edgeworth, Jonathan D Nebbia, Gaia |
| author_sort | Snell, Luke B |
| collection | PubMed |
| description | The management of coronavirus disease 2019 has become more complex due to the expansion of available therapies. The presence of severe acute respiratory syndrome coronavirus 2 variants and mutations further complicates treatment due to their differing susceptibilities to therapies. Here we outline the use of real-time whole genome sequencing to detect persistent infection, evaluate for mutations confering resistance to treatments, and guide treatment decisions. |
| format | Online Article Text |
| id | pubmed-10029986 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | Oxford University Press |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-100299862023-03-22 Real-Time Whole Genome Sequencing to Guide Patient-Tailored Therapy of Severe Acute Respiratory Syndrome Coronavirus 2 Infection Snell, Luke B Alcolea-Medina, Adela Charalampous, Themoula Alder, Christopher Williams, Tom G S Flaviani, Flavia Batra, Rahul Bakrania, Prijay Thangarajah, Rajeni Neil, Stuart J D van Nispen tot Pannerden, Claire Botgros, Alina Aarons, Emma Douthwaite, Samuel T Edgeworth, Jonathan D Nebbia, Gaia Clin Infect Dis Brief Report The management of coronavirus disease 2019 has become more complex due to the expansion of available therapies. The presence of severe acute respiratory syndrome coronavirus 2 variants and mutations further complicates treatment due to their differing susceptibilities to therapies. Here we outline the use of real-time whole genome sequencing to detect persistent infection, evaluate for mutations confering resistance to treatments, and guide treatment decisions. Oxford University Press 2022-11-03 /pmc/articles/PMC10029986/ /pubmed/36327795 http://dx.doi.org/10.1093/cid/ciac864 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
| spellingShingle | Brief Report Snell, Luke B Alcolea-Medina, Adela Charalampous, Themoula Alder, Christopher Williams, Tom G S Flaviani, Flavia Batra, Rahul Bakrania, Prijay Thangarajah, Rajeni Neil, Stuart J D van Nispen tot Pannerden, Claire Botgros, Alina Aarons, Emma Douthwaite, Samuel T Edgeworth, Jonathan D Nebbia, Gaia Real-Time Whole Genome Sequencing to Guide Patient-Tailored Therapy of Severe Acute Respiratory Syndrome Coronavirus 2 Infection |
| title | Real-Time Whole Genome Sequencing to Guide Patient-Tailored Therapy of Severe Acute Respiratory Syndrome Coronavirus 2 Infection |
| title_full | Real-Time Whole Genome Sequencing to Guide Patient-Tailored Therapy of Severe Acute Respiratory Syndrome Coronavirus 2 Infection |
| title_fullStr | Real-Time Whole Genome Sequencing to Guide Patient-Tailored Therapy of Severe Acute Respiratory Syndrome Coronavirus 2 Infection |
| title_full_unstemmed | Real-Time Whole Genome Sequencing to Guide Patient-Tailored Therapy of Severe Acute Respiratory Syndrome Coronavirus 2 Infection |
| title_short | Real-Time Whole Genome Sequencing to Guide Patient-Tailored Therapy of Severe Acute Respiratory Syndrome Coronavirus 2 Infection |
| title_sort | real-time whole genome sequencing to guide patient-tailored therapy of severe acute respiratory syndrome coronavirus 2 infection |
| topic | Brief Report |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10029986/ https://www.ncbi.nlm.nih.gov/pubmed/36327795 http://dx.doi.org/10.1093/cid/ciac864 |
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