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COVID-19 and its continuing burden after 12 months: a longitudinal observational prospective multicentre trial

BACKGROUND: Recovery trajectories from coronavirus disease 2019 (COVID-19) call for longitudinal investigation. We aimed to characterise the kinetics and status of clinical, cardiopulmonary and mental health recovery up to 1 year following COVID-19. METHODS: Clinical evaluation, lung function testin...

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Detalles Bibliográficos
Autores principales: Sahanic, Sabina, Tymoszuk, Piotr, Luger, Anna K., Hüfner, Katharina, Boehm, Anna, Pizzini, Alex, Schwabl, Christoph, Koppelstätter, Sabine, Kurz, Katharina, Asshoff, Malte, Mosheimer-Feistritzer, Birgit, Coen, Maximilian, Pfeifer, Bernhard, Rass, Verena, Egger, Alexander, Hörmann, Gregor, Sperner-Unterweger, Barbara, Helbok, Raimund, Wöll, Ewald, Weiss, Günter, Widmann, Gerlig, Tancevski, Ivan, Sonnweber, Thomas, Löffler-Ragg, Judith
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Respiratory Society 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10030059/
https://www.ncbi.nlm.nih.gov/pubmed/36960350
http://dx.doi.org/10.1183/23120541.00317-2022
Descripción
Sumario:BACKGROUND: Recovery trajectories from coronavirus disease 2019 (COVID-19) call for longitudinal investigation. We aimed to characterise the kinetics and status of clinical, cardiopulmonary and mental health recovery up to 1 year following COVID-19. METHODS: Clinical evaluation, lung function testing (LFT), chest computed tomography (CT) and transthoracic echocardiography were conducted at 2, 3, 6 and 12 months after disease onset. Submaximal exercise capacity, mental health status and quality of life were assessed at 12 months. Recovery kinetics and patterns were investigated by mixed-effect logistic modelling, correlation and clustering analyses. Risk of persistent symptoms and cardiopulmonary abnormalities at the 1-year follow-up were modelled by logistic regression. FINDINGS: Out of 145 CovILD study participants, 108 (74.5%) completed the 1-year follow-up (median age 56.5 years; 59.3% male; 24% intensive care unit patients). Comorbidities were present in 75% (n=81). Key outcome measures plateaued after 180 days. At 12 months, persistent symptoms were found in 65% of participants; 33% suffered from LFT impairment; 51% showed CT abnormalities; and 63% had low-grade diastolic dysfunction. Main risk factors for cardiopulmonary impairment included pro-inflammatory and immunological biomarkers at early visits. In addition, we deciphered three recovery clusters separating almost complete recovery from patients with post-acute inflammatory profile and an enrichment in cardiopulmonary residuals from a female-dominated post-COVID-19 syndrome with reduced mental health status. CONCLUSION: 1 year after COVID-19, the burden of persistent symptoms, impaired lung function, radiological abnormalities remains high in our study population. Yet, three recovery trajectories are emerging, ranging from almost complete recovery to post-COVID-19 syndrome with impaired mental health.