Cargando…

Iron status influences mitochondrial disease progression in Complex I-deficient mice

Mitochondrial dysfunction caused by aberrant Complex I assembly and reduced activity of the electron transport chain is pathogenic in many genetic and age-related diseases. Mice missing the Complex I subunit NADH dehydrogenase [ubiquinone] iron-sulfur protein 4 (NDUFS4) are a leading mammalian model...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kelly, CJ, Couch, Reid K, Ha, Vivian T, Bodart, Camille M, Wu, Judy, Huff, Sydney, Herrel, Nicole T, Kim, Hyunsung D, Zimmermann, Azaad O, Shattuck, Jessica, Pan, Yu-Chen, Kaeberlein, Matt, Grillo, Anthony S
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2023
Materias:	Biochemistry and Chemical Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10030112/ https://www.ncbi.nlm.nih.gov/pubmed/36799301 http://dx.doi.org/10.7554/eLife.75825

Ejemplares similares

A physicochemical perspective of aging from single-cell analysis of pH, macromolecular and organellar crowding in yeast
por: Mouton, Sara N, et al.
Publicado: (2020)

Mechanisms of iron- and O(2)-sensing by the [4Fe-4S] cluster of the global iron regulator RirA
por: Pellicer Martinez, Ma Teresa, et al.
Publicado: (2019)

Changes in ferrous iron and glutathione promote ferroptosis and frailty in aging Caenorhabditis elegans
por: Jenkins, Nicole L, et al.
Publicado: (2020)

Preacinetobactin not acinetobactin is essential for iron uptake by the BauA transporter of the pathogen Acinetobacter baumannii
por: Moynié, Lucile, et al.
Publicado: (2018)

Large protein organelles form a new iron sequestration system with high storage capacity
por: Giessen, Tobias W, et al.
Publicado: (2019)

Short-chain fatty acids activate acetyltransferase p300
por: Thomas, Sydney P, et al.
Publicado: (2021)

Iron derived from autophagy-mediated ferritin degradation induces cardiomyocyte death and heart failure in mice
por: Ito, Jumpei, et al.
Publicado: (2021)

Spreading of a mycobacterial cell-surface lipid into host epithelial membranes promotes infectivity
por: Cambier, CJ, et al.
Publicado: (2020)

Cellular assays identify barriers impeding iron-sulfur enzyme activity in a non-native prokaryotic host
por: D'Angelo, Francesca, et al.
Publicado: (2022)

Haploinsufficiency of Trp53 dramatically extends the lifespan of Sirt6-deficient mice
por: Ghosh, Shrestha, et al.
Publicado: (2018)

Mitochondrial redox adaptations enable alternative aspartate synthesis in SDH-deficient cells
por: Hart, Madeleine L, et al.
Publicado: (2023)

Transcriptomic and proteomic landscape of mitochondrial dysfunction reveals secondary coenzyme Q deficiency in mammals
por: Kühl, Inge, et al.
Publicado: (2017)

Explosive mutation accumulation triggered by heterozygous human Pol ε proofreading-deficiency is driven by suppression of mismatch repair
por: Hodel, Karl P, et al.
Publicado: (2018)

The two shapes of the Tau protein
por: Kelly, Jeffery W
Publicado: (2018)

Multiple serine transposase dimers assemble the transposon-end synaptic complex during IS607-family transposition
por: Chen, Wenyang, et al.
Publicado: (2018)

A coarse-grained NADH redox model enables inference of subcellular metabolic fluxes from fluorescence lifetime imaging
por: Yang, Xingbo, et al.
Publicado: (2021)

NusG is an intrinsic transcription termination factor that stimulates motility and coordinates gene expression with NusA
por: Mandell, Zachary F, et al.
Publicado: (2021)

In vitro proteasome processing of neo-splicetopes does not predict their presentation in vivo
por: Willimsky, Gerald, et al.
Publicado: (2021)

Functional instability allows access to DNA in longer transcription Activator-Like effector (TALE) arrays
por: Geiger-Schuller, Kathryn, et al.
Publicado: (2019)

Stereospecific lasofoxifene derivatives reveal the interplay between estrogen receptor alpha stability and antagonistic activity in ESR1 mutant breast cancer cells
por: Hosfield, David J, et al.
Publicado: (2022)

The human gut chemical landscape predicts microbe-mediated biotransformation of foods and drugs
por: Guthrie, Leah, et al.
Publicado: (2019)

Identification of a novel toxicophore in anti-cancer chemotherapeutics that targets mitochondrial respiratory complex I
por: Stephenson, Zoe A, et al.
Publicado: (2020)

APE1 recruits ATRIP to ssDNA in an RPA-dependent and -independent manner to promote the ATR DNA damage response
por: Lin, Yunfeng, et al.
Publicado: (2023)

Pharmacologic ATF6 activating compounds are metabolically activated to selectively modify endoplasmic reticulum proteins
por: Paxman, Ryan, et al.
Publicado: (2018)

Synthetic single domain antibodies for the conformational trapping of membrane proteins
por: Zimmermann, Iwan, et al.
Publicado: (2018)

Regulation of mRNA translation by a photoriboswitch
por: Rotstan, Kelly A, et al.
Publicado: (2020)

HDX-MS reveals structural determinants for RORγ hyperactivation by synthetic agonists
por: Strutzenberg, Timothy S, et al.
Publicado: (2019)

Correction: HDX-MS reveals structural determinants for RORγ hyperactivation by synthetic agonists
por: Strutzenberg, Timothy S, et al.
Publicado: (2019)

Deep transcriptome annotation enables the discovery and functional characterization of cryptic small proteins
por: Samandi, Sondos, et al.
Publicado: (2017)

Protomer alignment modulates specificity of RNA substrate recognition by Ire1
por: Li, Weihan, et al.
Publicado: (2021)

Protein quality control in the nucleolus safeguards recovery of epigenetic regulators after heat shock
por: Azkanaz, Maria, et al.
Publicado: (2019)

Mechanisms of opening and closing of the bacterial replicative helicase
por: Chase, Jillian, et al.
Publicado: (2018)

Activin A forms a non-signaling complex with ACVR1 and type II Activin/BMP receptors via its finger 2 tip loop
por: Aykul, Senem, et al.
Publicado: (2020)

Molecular basis for activation of lecithin:cholesterol acyltransferase by a compound that increases HDL cholesterol
por: Manthei, Kelly A, et al.
Publicado: (2018)

Dissection of affinity captured LINE-1 macromolecular complexes
por: Taylor, Martin S, et al.
Publicado: (2018)

Pharmacological targeting of the transcription factor SOX18 delays breast cancer in mice
por: Overman, Jeroen, et al.
Publicado: (2017)

Correction: Pharmacological targeting of the transcription factor SOX18 delays breast cancer in mice
por: Overman, Jeroen, et al.
Publicado: (2023)

Bridging a gap in iron-sulfur cluster assembly
por: McCarthy, Erin L., et al.
Publicado: (2015)

Positively selected modifications in the pore of TbAQP2 allow pentamidine to enter Trypanosoma brucei
por: Alghamdi, Ali H, et al.
Publicado: (2020)

FRET-based dynamic structural biology: Challenges, perspectives and an appeal for open-science practices
por: Lerner, Eitan, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_jtn7tats5fg6cakaakoo7bv874