Membrane phosphoinositides regulate GPCR-β-arrestin complex assembly and dynamics

Binding of arrestin to phosphorylated G protein-coupled receptors (GPCRs) is crucial for modulating signaling. Once internalized, some GPCRs remain complexed with β-arrestins, while others interact only transiently; this difference affects GPCR signaling and recycling. Cell-based and in vitro biophy...

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Detalles Bibliográficos
Autores principales: Janetzko, John, Kise, Ryoji, Barsi-Rhyne, Benjamin, Siepe, Dirk H., Heydenreich, Franziska M., Kawakami, Kouki, Masureel, Matthieu, Maeda, Shoji, Garcia, K. Christopher, von Zastrow, Mark, Inoue, Asuka, Kobilka, Brian K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10030194/
https://www.ncbi.nlm.nih.gov/pubmed/36368322
http://dx.doi.org/10.1016/j.cell.2022.10.018

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