The essential effect of mTORC1-dependent lipophagy in non-alcoholic fatty liver disease

Non-alcoholic fatty liver disease (NAFLD) is a chronic progressive liver disease with increasing prevalence. Lipophagy is a type of programmed cell death that plays an essential role in maintaining the body’s balance of fatty acid metabolism. However, the livers of NAFLD patients are abnormally dysr...

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Autores principales: Tan, Xiangyun, Huang, Xinyu, Lu, Zhuhang, Chen, Liang, Hu, Junjie, Tian, Xianxiang, Qiu, Zhenpeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10030502/
https://www.ncbi.nlm.nih.gov/pubmed/36969837
http://dx.doi.org/10.3389/fphar.2023.1124003
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author Tan, Xiangyun
Huang, Xinyu
Lu, Zhuhang
Chen, Liang
Hu, Junjie
Tian, Xianxiang
Qiu, Zhenpeng
author_facet Tan, Xiangyun
Huang, Xinyu
Lu, Zhuhang
Chen, Liang
Hu, Junjie
Tian, Xianxiang
Qiu, Zhenpeng
author_sort Tan, Xiangyun
collection PubMed
description Non-alcoholic fatty liver disease (NAFLD) is a chronic progressive liver disease with increasing prevalence. Lipophagy is a type of programmed cell death that plays an essential role in maintaining the body’s balance of fatty acid metabolism. However, the livers of NAFLD patients are abnormally dysregulated in lipophagy. mTORC1 is a critical negative regulator of lipophagy, which has been confirmed to participate in the process of lipophagy through various complex mechanisms. Therefore, targeting mTORC1 to restore failed autophagy may be an effective therapeutic strategy for NAFLD. This article reviews the main pathways through which mTORC1 participates in the formation of lipophagy and the intervention effect of mTORC1-regulated lipophagy in NAFLD, providing new therapeutic strategies for the prevention and treatment of NAFLD in the future.
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spelling pubmed-100305022023-03-23 The essential effect of mTORC1-dependent lipophagy in non-alcoholic fatty liver disease Tan, Xiangyun Huang, Xinyu Lu, Zhuhang Chen, Liang Hu, Junjie Tian, Xianxiang Qiu, Zhenpeng Front Pharmacol Pharmacology Non-alcoholic fatty liver disease (NAFLD) is a chronic progressive liver disease with increasing prevalence. Lipophagy is a type of programmed cell death that plays an essential role in maintaining the body’s balance of fatty acid metabolism. However, the livers of NAFLD patients are abnormally dysregulated in lipophagy. mTORC1 is a critical negative regulator of lipophagy, which has been confirmed to participate in the process of lipophagy through various complex mechanisms. Therefore, targeting mTORC1 to restore failed autophagy may be an effective therapeutic strategy for NAFLD. This article reviews the main pathways through which mTORC1 participates in the formation of lipophagy and the intervention effect of mTORC1-regulated lipophagy in NAFLD, providing new therapeutic strategies for the prevention and treatment of NAFLD in the future. Frontiers Media S.A. 2023-03-08 /pmc/articles/PMC10030502/ /pubmed/36969837 http://dx.doi.org/10.3389/fphar.2023.1124003 Text en Copyright © 2023 Tan, Huang, Lu, Chen, Hu, Tian and Qiu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Tan, Xiangyun
Huang, Xinyu
Lu, Zhuhang
Chen, Liang
Hu, Junjie
Tian, Xianxiang
Qiu, Zhenpeng
The essential effect of mTORC1-dependent lipophagy in non-alcoholic fatty liver disease
title The essential effect of mTORC1-dependent lipophagy in non-alcoholic fatty liver disease
title_full The essential effect of mTORC1-dependent lipophagy in non-alcoholic fatty liver disease
title_fullStr The essential effect of mTORC1-dependent lipophagy in non-alcoholic fatty liver disease
title_full_unstemmed The essential effect of mTORC1-dependent lipophagy in non-alcoholic fatty liver disease
title_short The essential effect of mTORC1-dependent lipophagy in non-alcoholic fatty liver disease
title_sort essential effect of mtorc1-dependent lipophagy in non-alcoholic fatty liver disease
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10030502/
https://www.ncbi.nlm.nih.gov/pubmed/36969837
http://dx.doi.org/10.3389/fphar.2023.1124003
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