Early Lifetime Substance Use and Development of Visual Impairment: Analysis of the National Survey on Drug Use and Health Data

PURPOSE: To investigate the association between early lifetime substance use on the development of severe visual acuity impairment or blindness on a national level. METHODS: National Survey of Drug Use and Health data was used to identify cases of substance use before 21* years of age, within the pa...

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Detalles Bibliográficos
Autores principales: Hussain, Zain S, Khan, Asher, Loya, Asad, Shah, Kaushal, Woreta, Fasika A, Riaz, Kamran M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10030542/
https://www.ncbi.nlm.nih.gov/pubmed/36968284
http://dx.doi.org/10.2147/OPTH.S401167
Descripción
Sumario:PURPOSE: To investigate the association between early lifetime substance use on the development of severe visual acuity impairment or blindness on a national level. METHODS: National Survey of Drug Use and Health data was used to identify cases of substance use before 21* years of age, within the past year, and cases of self-reported blindness or visual impairment. Univariable and multivariable binary logistic regression with time-dependency was performed to evaluate odds of visual impairment influenced by 16 substances separated into three classes: prescription, non-prescription, and illicit drugs. Adjusted variables of interest included gender, marital status, race, level of education, total family income, poverty level, population density, and history of chronic disease. RESULTS: 55,824 total responses were analyzed with 2577 (4.6%) cases of self-reported blindness or significant visual impairment. All early-use substance categories, including prescription, non-prescription, and illegal substances, were significantly associated with self-reported VI (OR 2.068, CI 1.451–2.949, p<0.001; OR 1.352, CI 1.227–1.489, p<0.001); OR 1.211, CI 1.086–1.352, p<0.001), respectively). Non-prescription substances displayed parallel significances amongst all constituents (alcohol, cigarettes, inhalants, and marijuana) (OR=1.227, CI 1.12–1.344, p<0.001; OR 1.363, CI 1.243–1.495, p<0.001; OR 1.418, CI 1.134–1.774; OR 1.388, CI 1.27–1.518, p<0.001, respectively). Univariable and multivariable analysis revealed several significant demographical and clinical adjustors. CONCLUSION: Early lifetime use of all three classes of substances is associated with enhanced odds of subsequent visual impairment or blindness. Several readily available and commonly used substances have a greater risk. These findings may help clinicians and public health agencies in mitigation ventures including education, prevention, and rehabilitation efforts.

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