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author Bandeira, Matilde
Dourado, Eduardo
Melo, Ana Teresa
Martins, Patrícia
Fraga, Vanessa
Ferraro, José Luís
Saraiva, André
Sousa, Marlene
Parente, Hugo
Soares, Catarina
Correia, Ana Margarida
Almeida, Diogo Esperança
Dinis, Sara Paiva
Pinto, Ana Sofia
Oliveira Pinheiro, Filipe
Rato, Maria Seabra
Beirão, Tiago
Samões, Beatriz
Santos, Bernardo
Mazeda, Carolina
Chícharo, Ana Teodósio
Faria, Margarida
Neto, Agna
Lourenço, Maria Helena
Brites, Luísa
Rodrigues, Marília
Silva-Dinis, Joana
Dias, João Madruga
Araújo, Filipe C.
Martins, Nádia
Couto, Maura
Valido, Ana
Santos, Maria José
Barreira, Sofia Carvalho
Fonseca, João Eurico
Campanilho-Marques, Raquel
author_facet Bandeira, Matilde
Dourado, Eduardo
Melo, Ana Teresa
Martins, Patrícia
Fraga, Vanessa
Ferraro, José Luís
Saraiva, André
Sousa, Marlene
Parente, Hugo
Soares, Catarina
Correia, Ana Margarida
Almeida, Diogo Esperança
Dinis, Sara Paiva
Pinto, Ana Sofia
Oliveira Pinheiro, Filipe
Rato, Maria Seabra
Beirão, Tiago
Samões, Beatriz
Santos, Bernardo
Mazeda, Carolina
Chícharo, Ana Teodósio
Faria, Margarida
Neto, Agna
Lourenço, Maria Helena
Brites, Luísa
Rodrigues, Marília
Silva-Dinis, Joana
Dias, João Madruga
Araújo, Filipe C.
Martins, Nádia
Couto, Maura
Valido, Ana
Santos, Maria José
Barreira, Sofia Carvalho
Fonseca, João Eurico
Campanilho-Marques, Raquel
author_sort Bandeira, Matilde
collection PubMed
description OBJECTIVES: Idiopathic inflammatory myopathies (IIM) are a group of rare disorders that can affect the heart. This work aimed to find predictors of cardiac involvement in IIM. METHODS: Multicenter, open cohort study, including patients registered in the IIM module of the Rheumatic Diseases Portuguese Register (Reuma.pt/Myositis) until January 2022. Patients without cardiac involvement information were excluded. Myo(peri)carditis, dilated cardiomyopathy, conduction abnormalities, and/or premature coronary artery disease were considered. RESULTS: 230 patients were included, 163 (70.9%) of whom were females. Thirteen patients (5.7%) had cardiac involvement. Compared with IIM patients without cardiac involvement, these patients had a lower bilateral manual muscle testing score (MMT) at the peak of muscle weakness [108.0 ± 55.0 vs 147.5 ± 22.0, p=0.008] and more frequently had oesophageal [6/12 (50.0%) vs 33/207 (15.9%), p=0.009] and lung [10/13 (76.9%) vs 68/216 (31.5%), p=0.001] involvements. Anti-SRP antibodies were more commonly identified in patients with cardiac involvement [3/11 (27.3%) vs 9/174 (5.2%), p=0.026]. In the multivariate analysis, positivity for anti-SRP antibodies (OR 104.3, 95% CI: 2.5-4277.8, p=0.014) was a predictor of cardiac involvement, regardless of sex, ethnicity, age at diagnosis, and lung involvement. Sensitivity analysis confirmed these results. CONCLUSION: Anti-SRP antibodies were predictors of cardiac involvement in our cohort of IIM patients, irrespective of demographical characteristics and lung involvement. We suggest considering frequent screening for heart involvement in anti-SRP-positive IIM patients.
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spelling pubmed-100307052023-03-23 Predictors of cardiac involvement in idiopathic inflammatory myopathies Bandeira, Matilde Dourado, Eduardo Melo, Ana Teresa Martins, Patrícia Fraga, Vanessa Ferraro, José Luís Saraiva, André Sousa, Marlene Parente, Hugo Soares, Catarina Correia, Ana Margarida Almeida, Diogo Esperança Dinis, Sara Paiva Pinto, Ana Sofia Oliveira Pinheiro, Filipe Rato, Maria Seabra Beirão, Tiago Samões, Beatriz Santos, Bernardo Mazeda, Carolina Chícharo, Ana Teodósio Faria, Margarida Neto, Agna Lourenço, Maria Helena Brites, Luísa Rodrigues, Marília Silva-Dinis, Joana Dias, João Madruga Araújo, Filipe C. Martins, Nádia Couto, Maura Valido, Ana Santos, Maria José Barreira, Sofia Carvalho Fonseca, João Eurico Campanilho-Marques, Raquel Front Immunol Immunology OBJECTIVES: Idiopathic inflammatory myopathies (IIM) are a group of rare disorders that can affect the heart. This work aimed to find predictors of cardiac involvement in IIM. METHODS: Multicenter, open cohort study, including patients registered in the IIM module of the Rheumatic Diseases Portuguese Register (Reuma.pt/Myositis) until January 2022. Patients without cardiac involvement information were excluded. Myo(peri)carditis, dilated cardiomyopathy, conduction abnormalities, and/or premature coronary artery disease were considered. RESULTS: 230 patients were included, 163 (70.9%) of whom were females. Thirteen patients (5.7%) had cardiac involvement. Compared with IIM patients without cardiac involvement, these patients had a lower bilateral manual muscle testing score (MMT) at the peak of muscle weakness [108.0 ± 55.0 vs 147.5 ± 22.0, p=0.008] and more frequently had oesophageal [6/12 (50.0%) vs 33/207 (15.9%), p=0.009] and lung [10/13 (76.9%) vs 68/216 (31.5%), p=0.001] involvements. Anti-SRP antibodies were more commonly identified in patients with cardiac involvement [3/11 (27.3%) vs 9/174 (5.2%), p=0.026]. In the multivariate analysis, positivity for anti-SRP antibodies (OR 104.3, 95% CI: 2.5-4277.8, p=0.014) was a predictor of cardiac involvement, regardless of sex, ethnicity, age at diagnosis, and lung involvement. Sensitivity analysis confirmed these results. CONCLUSION: Anti-SRP antibodies were predictors of cardiac involvement in our cohort of IIM patients, irrespective of demographical characteristics and lung involvement. We suggest considering frequent screening for heart involvement in anti-SRP-positive IIM patients. Frontiers Media S.A. 2023-03-08 /pmc/articles/PMC10030705/ /pubmed/36969246 http://dx.doi.org/10.3389/fimmu.2023.1146817 Text en Copyright © 2023 Bandeira, Dourado, Melo, Martins, Fraga, Ferraro, Saraiva, Sousa, Parente, Soares, Correia, Almeida, Dinis, Pinto, Oliveira Pinheiro, Rato, Beirão, Samões, Santos, Mazeda, Chícharo, Faria, Neto, Lourenço, Brites, Rodrigues, Silva-Dinis, Dias, Araújo, Martins, Couto, Valido, Santos, Barreira, Fonseca and Campanilho-Marques https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Bandeira, Matilde
Dourado, Eduardo
Melo, Ana Teresa
Martins, Patrícia
Fraga, Vanessa
Ferraro, José Luís
Saraiva, André
Sousa, Marlene
Parente, Hugo
Soares, Catarina
Correia, Ana Margarida
Almeida, Diogo Esperança
Dinis, Sara Paiva
Pinto, Ana Sofia
Oliveira Pinheiro, Filipe
Rato, Maria Seabra
Beirão, Tiago
Samões, Beatriz
Santos, Bernardo
Mazeda, Carolina
Chícharo, Ana Teodósio
Faria, Margarida
Neto, Agna
Lourenço, Maria Helena
Brites, Luísa
Rodrigues, Marília
Silva-Dinis, Joana
Dias, João Madruga
Araújo, Filipe C.
Martins, Nádia
Couto, Maura
Valido, Ana
Santos, Maria José
Barreira, Sofia Carvalho
Fonseca, João Eurico
Campanilho-Marques, Raquel
Predictors of cardiac involvement in idiopathic inflammatory myopathies
title Predictors of cardiac involvement in idiopathic inflammatory myopathies
title_full Predictors of cardiac involvement in idiopathic inflammatory myopathies
title_fullStr Predictors of cardiac involvement in idiopathic inflammatory myopathies
title_full_unstemmed Predictors of cardiac involvement in idiopathic inflammatory myopathies
title_short Predictors of cardiac involvement in idiopathic inflammatory myopathies
title_sort predictors of cardiac involvement in idiopathic inflammatory myopathies
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10030705/
https://www.ncbi.nlm.nih.gov/pubmed/36969246
http://dx.doi.org/10.3389/fimmu.2023.1146817
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